Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.

By J. Repa, S. Turley, J. Lobaccaro, J. Medina, Lu Li, K. Lustig, B. Shan, R. Heyman, J. Dietschy, D. Mangelsdorf. Science, 2000

1,371 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/e0765bb397966704c3a29e12dff8b57a575cdd10

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. P. Tontonoz
2. D. Mangelsdorf
3. Christopher K. Glass
4. A. Calkin
5. J. Goldstein
6. Michael S. Brown
7. Michael G. Rosenfeld
8. R. Evans

In Oncology

1. P. Tontonoz
2. J. Goldstein
3. D. Mangelsdorf
4. Michael S. Brown
5. A. Calkin
6. P. Edwards
7. J. Repa
8. Christopher K. Glass

In Surgery

1. P. Tontonoz
2. J. Goldstein
3. D. Mangelsdorf
4. Michael S. Brown
5. A. Calkin
6. Christopher K. Glass
7. P. Edwards
8. J. Repa

Citations in the corpus

• Liver X receptor signaling pathways in cardiovascular disease. (2003, background): “Because LXR/RXR heterodimers are permissive heterodimers that respond to agonists for both receptors, it is not surprising that RXR agonists mimic many of the effects of LXR activators including induction of ABCA1 and reverse cholesterol transport in macrophages (13, 65).”
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “LXR agonists robustly induce ABCA1 expression in an LXR-dependent manner not only in macrophages but also in many tissues of the periphery such as the intestin”
• A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis (2001, positive): “Previous work has shown that the human ABCA1 gene is regulated by the LXR/ hydroxycholesterol resulted in a marked induction of ABCA1 and ABCG1 (Figure 3C), consistent with the re- RXR heterodimer (Costet et al., 2000; Repa et al., 2000; Schwartz et al., 2000; Venkateswaran et al., 2000a).”
• A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. (2001, result): “Previous work has shown that the human ABCA1 gene is regulated by the LXR/ hydroxycholesterol resulted in a marked induction of ABCA1 and ABCG1 (Figure 3C), consistent with the re- RXR heterodimer (Costet et al., 2000; Repa et al., 2000; Schwartz et al., 2000; Venkateswaran et al., 2000a).”
• Atherosclerosis The Road Ahead (2001, background): “In addition, the ABC-A1 gene is several aspects of fatty acid metabolism, including beta regulated in the intestine and in macrophages by LXRs oxidation and uptake of fatty acids from triglyceride- (Costet et al., 2000; Repa et al., 2000b).”