A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.

By A. Chawla, W. Boisvert, Chih‐Hao Lee, B. Laffitte, Y. Barak, S. Joseph, D. Liao, L. Nagy, Peter A. Edwards, L. Curtiss and 2 more. Molecules and Cells, 2001

598 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aa033da5ebeae49394bf72af67b3fb4fe93517b8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. M. Matsuda
2. M. Iwaki
3. N. Maeda
4. I. Shimomura
5. Yuji Matsuzawa
6. T. Funahashi
7. K. Matsusue
8. M. Haluzík

Citations in the corpus

• Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. (2003, methodology): “A: The PPRE sequence in human adiponectin promoter is compared with the PPRE sequences in the promoters of various PPAR- –responsive genes: mouse aP2 PPRE, ARE6, and ARE7 (36); mouse c-Cbl–associating protein PPRE (39); mouse LXR PPRE (40); and mouse AQPap (aquaporin adipose) PPRE (35).”
• The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses (2020, background): “Notably, not only cholesterol uptake but also efflux, mediated by the cholesterol efflux cassettes of the ABCA1 family, is under the transcriptional control of PPARγ [63].”
• Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. (2003, background): “PPARγ is known to activate the expression of LXRα in macrophages (4, 5).”