A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

By A. Chawla, W. Boisvert, Chih‐Hao Lee, B. Laffitte, Y. Barak, S. Joseph, D. Liao, L. Nagy, P. Edwards, L. Curtiss and 2 more. 2001

1,253 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/02f45188784f1f3aacdbe38d8a1e09c991d28bd0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Moller
2. Christopher K. Glass
3. P. Tontonoz
4. David J. Loane
5. Alok Kumar

In Molecular Biology

1. P. Tontonoz
2. Christopher K. Glass
3. D. Mangelsdorf
4. D. Moller
5. David J. Loane
6. Alok Kumar
7. I. Tabas

In Surgery

1. P. Tontonoz
2. D. Mangelsdorf
3. Christopher K. Glass
4. P. Calder
5. I. Tabas
6. K. Moore
7. S. Bensinger

Citations in the corpus

• Liver X receptor signaling pathways in cardiovascular disease. (2003, background): “null bone marrow into LDLR knockout mice also increases atherosclerosis (71), suggesting that PPAR LXR cross-talk may be important for atherosclerosis susceptibility.”
• The mechanisms of action of PPARs. (2002, background): “Two recent studies have suggested that either PPARα (154) or PPARγ (154, 155) activation in macrophages can induce the expression of a cholesterol efflux “pump” known as ABC-A1.”
• Atherosclerosis The Road Ahead (2001, background): “Estrogen receptors are important targets of rophages by a mechanism involving induction of LXRa drugs for breast cancer and hormone replacement ther- (Chawla et al., 2001).”