Liver X receptor signaling pathways in cardiovascular disease.

By P. Tontonoz, D. Mangelsdorf. Molecular Endocrinology, 2003

657 citations recorded by the source corpus.

Subfields: Biochemistry, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/f89829a0da5a89ea2f2fc1c0f27bf1d8386b1566

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Elina Ikonen
2. P. Tontonoz

In Oncology

1. P. Tontonoz
2. S. Bensinger
3. Elina Ikonen
4. N. Zelcer
5. D. Mangelsdorf
6. P. Edwards
7. J. Y. Chiang

In Surgery

1. P. Tontonoz
2. S. Bensinger
3. N. Zelcer
4. D. Mangelsdorf
5. Elina Ikonen
6. P. Edwards
7. I. Tabas
8. A. Calkin

Citations in the corpus

• Cellular cholesterol trafficking and compartmentalization (2008, background): “, whereas LXR activation facilitates reverse cholesterol transport; that is, processes leading to cholesterol removal from peripheral cells and increased biliary sterol secretio”
• Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, neutral): “LXR in turn activates transcription of Mer, thereby providing positive feedback to promote further clearance, as well as genes such as Abca1 and Abcg1 to promote efflux of the excess cholesterol (Tontonoz and Mangelsdorf, 2003).”
• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “…Vennstrom, 2000; Marrif et al., 2005), MR is the primary rheostat for blood pressure (Gomez-Sanchez et al., 1996; Le Menuet et al., 2004), and LXRb modulates expression of proteins that stimulate reverse-cholesterol transport and remodeling of serum lipoproteins (Tontonoz and Mangelsdorf, 2003).”
• Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “LXR-α and LXR-β have considerable sequence homology (∼77p identity in DNA- and ligand-binding domains), seem to respond to the same endogenous ligands, and have almost identical target gene”
• LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “Many LXR target genes are involved in cholesterol and fatty acid metabolism, such as ABCA1, ABCG1, SREBP-1c, and fatty acid synthase (Tontonoz and Mangelsdorf, 2003).”
• Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. (2007, background): “The LXR agonist GW3965 was obtained from GlaxoSmithKline and has been described previously (31).”