Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

By E. Brakenhielm, Niina Veitonmäki, R. Cao, S. Kihara, Yuji Matsuzawa, B. Zhivotovsky, T. Funahashi, Yihai Cao. Proceedings of the National Academy of Sciences of the United States of America, 2004

749 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/e0447d10f6f2e96aa547e66f95148023aaed69c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Herbert Tilg
2. A. Moschen
3. Takashi Kadowaki
4. Toshimasa Yamauchi
5. S. Harrison
6. Barry J. Goldstein
7. Rosario Scalia
8. S. Caldwell

In Immunology

1. Barry J. Goldstein
2. Rosario Scalia
3. P. Trayhurn

In Oncology

1. R. C. V. van Kruijsdijk
2. E. van der Wall
3. Barry J. Goldstein
4. Rosario Scalia
5. F. Visseren

Citations in the corpus

• Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “In a mouse tumour model, adiponectin markedly inhibited primary tumour growth in a caspase-dependent manner and it resulted in endothelial-cell apoptosi”
• Hypoxia and adipose tissue function and dysfunction in obesity. (2013, background): “Since, as noted above, adiponectin has both anti-inflammatory and insulin-sensitizing actions, and may act as an angiogenesis inhibitor (14), the hypoxiaPAUL TRAYHURN”
• Adiponectin: A novel adipokine linking adipocytes and vascular function. (2004, positive): “and colleagues (42) is mediated by specific cellular caspases”
• Adiponectin: action, regulation and association to insulin sensitivity (2005, background): “Adiponectin has various biological functions including insulin sensitizing (27), anti-atherogenic (45), antiinflammatory (49), anti-angiogenic and anti-tumour functions (50).”
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “Adiponectin also has been shown to inhibit tumor angiogenesis in in vitro experiments (75).”
• Adiponectin and adiponectin receptors. (2005, background): “Recently, adiponectin was reported to induce antiangiogenesis and antitumor activity via caspase-mediated endothelial cell apoptosis (95).”
• Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection (2010, background): “Adiponectin is an anti-inflammatory polypeptide specific to adipose tissue that is decreased in insulin-resistant states and has been shown to inhibit angiogenesis via modulation of apoptosis in an animal model.(115,116) These complex factors related to an insulin-resistant state, promote uninhibite”
• Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. (2012, background): “Low adiponectin levels may be insufficient to suppress endotoxin-mediated inflammatory signaling in Kupffer cells and other macrophages [70], to activate adenosine monophosphate kinase, an inhibitor of the mTOR oncogenic pathway [71], and to control angiogenesis, a pivotal mechanism of tumor growth ”