Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

By D. Lombard, F. Alt, Hwei-Ling Cheng, J. Bunkenborg, R. Streeper, R. Mostoslavsky, Jennifer Kim, G. Yancopoulos, D. Valenzuela, A. Murphy and 10 more. Molecular and Cellular Biology, 2007

1,216 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/55244dde95f41cab1ba5b11963c7dcfd87c5d16d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. E. Verdin
4. L. Guarente
5. M. Haigis
6. C. Cantó
7. R. Houtkooper
8. E. Seto

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. E. Verdin
4. C. Cantó
5. R. Houtkooper
6. M. Haigis
7. L. Guarente
8. Guido Kroemer

Citations in the corpus

• Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. (2010, background): “To investigate whether SIRT3 is required for CR to reduce oxidative stress, we fed SIRT3 knockout (KO) mice (Lombard et al., 2007) and wild-type (WT) Inc. (A–”
• SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, positive): “As shown previously (Hirschey et al., 2010; Lombard et al., 2007), SIRT3KO mice fed a SD showed a significant increase in global hyperacetylated mitochondrial proteins compared to WT mice (159% increase; Figure 2A).”
• The hallmarks of aging. (2013, background): “SIRT3, which is the main mitochondrial deacetylase (Lombard et al., 2007), targets many enzymes involved in energy metabolism, including components of the respiratory chain, tricarboxylic acid cycle, ketogenesis, and fatty acid b-oxidation (Giralt and Villarroya, 2012).”
• Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “Sirt3-deficient animals exhibit striking mitochondrial protein hyperacetylation, suggesting that SIRT3 is a major mitochondrial deacetylase [25].”
• Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. (2009, neutral): “School, Boston, Massachusetts, USA) (42).”
• SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress (2010, background): “SIRT3 / mice were healthy, and no outwardly observed phenotype was noted (Lombard et al., 2007); however, 7 of 20 female mice developed mammary gland tumors (Figure 6A) over 24 months (Figure 6B), while 0 SIRT3+/+ mice developed mammary tumors during the same period.”
• SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks (2013, neutral): “SIRT3 is the major deacetylase in mitochondria (Lombard et al., 2007).”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “SIRT3 deacetylates and activates GDH in vitro (290) and in vivo (207).”
• SIRT1 and other sirtuins in Metabolism (2013, background): “Upon fasting or calorie restriction, SIRT3 protein level and activity are upregulated in mitochondria [26] to promote fatty acid oxidation via deacetylating long-chainspecific acyl-coenzyme A dehydrogenase (LCAD) [71].”
• Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline (2012, background): “Lysates from SIRT3 Knockout An-imals— Mice deficient for the protein deacetylase SIRT3 show hyperacetylation of a wide variety of mitochondrial proteins (42).”
• A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis (2008, background): “Similar results have been recently reported (11).”
• Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, background): “Although the initial characterization of Sirt5-/- mice found no obvious defects in basal glucose, insulin, or lipid homeostasis [47,48], further work could Verdin et al.”
• Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5 (2014, background): “In contrast, SIRT5 has little influence on global lysine acetylation (Lombard et al., 2007).”
• Mitochondrial dysfunction in cell senescence and aging (2022, background): “SIRT3 plays a unique role as the main mitochondrial deacetylase (89).”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Together with mass spectrometry, these mutant mice will be invaluable for identifying new substrates for HATs and HDACs, as shown for Sirt3 / mice (Lombard et al., 2007).”