Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.

By Heather L. Wieman, J. Wofford, J. Rathmell. Molecular Biology of the Cell, 2007

602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/df61f14372948d793fed84aae46f4782cd03f34b

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Citations in the corpus

Signal transduction in cancer. (2015, neutral): “2010), and trafficking of GLUT1, which is the principle glucose transporter expressed in most cell types (Wieman et al. 2007).”
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. (2008, background): “First, it permits cells to increase the surface expression of nutrient transporters, enabling increased uptake of glucose, amino acids, and other nutrients (Barata et al., 2004; Edinger and Thompson, 2002; Roos et al., 2007; Wieman et al., 2007; Xu et al., 2005).”
Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions (2014, background): “HOW IS GLUCOSE USED BY IMMUNE CELLS TO PRODUCE ENERGY? Glucose is transported into T cells via the high affinity Glucose transporter 1 (Glut1), which is the major glucose transporter on T cells (14, 15).”
The PI3K pathway in human disease (2017, positive): “…of GLUT1 through multiple mechanisms, including activation of mTORC1 that indirectly elevates the expression of HIF1 a (Thomas et al., 2006; Wieman et al., 2007) and c-Myc (Os-thus et al., 2000), transcription factors that drive the expression of genes involved in glucose metabolism,…”
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited (2010, background): “Under physiological condition, for example, PI3K/ Akt signaling pathways play a critical role in promoting aerobic glycolysis in activated T cells in response to growth factors or cytokines stimulation [6].”
Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism (2018, background): “Glut-1, the main glucose transporter in T cells (Palmer et al., 2015), translocates to the cell surface upon activation to allow glucose uptake (Wieman et al., 2007).”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “…signaling through the protein kinase Akt can increase uptake of glucose by increasing expression of the glucose transporter Glut1 (Barthel et al 1999, Frauwirth et al 2002, Vander Heiden et al 2001), and maintaining its levels on the cell surface by preventing internalization (Wieman et al 2007).”
The Glucose Transporter Glut1 is Selectively Essential for CD4 T Cell Activation and Effector Function (2014, positive): “Metabolic Assays Glycolysis and glucose uptake assays were normalized to cell number and have been described previously (Wieman et al., 2007).”
Brick by brick: metabolism and tumor cell growth. (2008, background): “mTOR increases surface expression of glucose transporters, allowing cells to boost import of the major lipogenic precursor [39,40].”
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets (2011, methodology): “Glucose uptake, glycolysis, and lipid oxidation were measured as previously described (5, 7, 13).”
Acetyl coenzyme A: a central metabolite and second messenger. (2015, background): “First, AKT1 signaling is required for normal glucose uptake through plasma membrane glucose transporters (Wieman et al., 2007).”
Metabolic Regulation of T Lymphocytes (2013, background): “For example, Rab11 can promote increased endosomal recycling of Glut1 to the cell surface (59), whereas Rab7 promotes Glut1 trafficking to lysosomes (60, 61).”
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation (2018, background): “The stimulation of lymphoid cells leads to increased GLUT1 uptake of glucose by acting on mTOR protein [129].”