Acetyl coenzyme A: a central metabolite and second messenger.

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Spermidine in health and disease (2018, background): “Depletion of the cytosolic-nuclear pool of acetyl-CoA induces autophagy in culturedmammalian cells, and inmice, aging yeast, and flies (16, 17, 96), and thus may represent an important mode of action of CRMs that induce protein deacetylation (table S1) (7).”
Mitochondrial metabolism and cancer (2017, background): “Besides fueling the oxidative mode of the TCA, citrate can also be converted into acetyl-CoA for export to the cytoplasm and nucleus [4, 81], where it can either be employed for fatty acid and cholesterol synthesis (to support the membrane need associated with intense proliferation) or used for acet”
Mitochondrial dysfunction in pathophysiology of heart failure (2018, neutral): “org Volume 128 Number 9 September 2018 2015;3(3):202–211.”
The Metabolic Signature of Macrophage Responses (2019, background): “Through ACLY activity, cytosolic citrate positively regulates protein and histone acetylation (77).”
Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics (2017, background): “Ketone bodies contribute to compartmentalized pools of acetylCoA, a key intermediate that exhibits prominent roles in cellular metabolism (Pietrocola et al., 2015).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “, 2005), and free acetate all contribute to the generation of mitochondrial acetyl-CoA (Pietrocola et al., 2015) (Fig.”