Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.

By K. Aboody, Alice B. Brown, N. Rainov, Kate A. Bower, Shaoxiong Liu, Wendy Yang, J. Small, Ulrich Herrlinger, V. Ourednik, Peter McL. Black and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,242 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/df48beed10b788b0543ea38a62db5e0af1ce8c4a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Z. Kokaia
2. O. Lindvall
3. M. Schwartz
4. G. Martino
5. Richard J. Gilbertson
6. Helmut Kettenmann
7. D. Rowitch
8. S. Pluchino

In Developmental Neuroscience

1. M. Schwartz
2. S. Pluchino
3. G. Martino
4. Z. Kokaia
5. O. Lindvall
6. R. Galli
7. B. Reynolds
8. Richard J. Gilbertson

In Genetics

1. Angelo Luigi Vescovi
2. R. Galli
3. B. Reynolds
4. Richard J. Gilbertson
5. Eric C. Holland
6. R. DePinho

Citations in the corpus

• The therapeutic potential of neural stem cells (2006, methodology): “Following the first observation in experimental brain tumour”
• Brain tumour stem cells (2006, background): “Similarly, immortalized neural stem cells that were placed near the tumour or at a distant site through intravascular delivery could migrate towards and integrate with the previously implanted tumour cell”
• Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. (2005, background): “Accumulation of normal stem cells in experimental tumors in vivo has been demonstrated in several studies (45, 46).”
• Malignant glioma: genetics and biology of a grave matter. (2001, background): “A recent study exploited the migratory property of neural stem cells for delivery of a cytotoxic drug to remote sites of implanted tumor cells (Aboody et al. 2000).”
• Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. (2005, background): “were among the first to show that after intracranial injection neural stem cells have a tropism for brain tumors that could be exploited therapeutically (7).”
• Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis (2003, background): “Somatic stem cells can target injured CNS tissue and promote functional recover”
• Diffuse glioma growth: a guerilla war (2007, background): “In orthotopic glioma models injection of NSCs transduced with the gene for cytosine deaminase led to a strong reduction of tumor burden [1].”
• Neuronal replacement from endogenous precursors in the adult brain after stroke (2002, background): “Such signals could also explain why transplanted neuronal precursors and neuroepithelial stem cells migrate to a tumo”
• The brain tumor microenvironment (2011, background): “The attraction of NPCs to experimental glioblastoma was initially observed with exogenously cultivated and immor- GLIA talized precursors (Aboody et al., 2000).”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Following the first observation in experimental brain tumors (2), the systemic (e.”
• Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model (2004, positive): “Aboody et al(10) demonstrated that neural stem cells (NSCs) administered intracranially possess extensive tropism for experimental glioma and significant migratory behavior. NSCs distribute throughout the primary tumor bed and migrate together with widely outgrowing tumor microsatellites after intra”