Complete Replication of Hepatitis C Virus in Cell Culture

By B. Lindenbach, M. Evans, A. Syder, B. Wölk, T. Tellinghuisen, Christopher C. Liu, T. Maruyama, R. Hynes, D. Burton, J. McKeating and 1 more. Science, 2005

2,408 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/deadacc24708babd1ed80df9be939e7f177f3982

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Citations in the corpus

Hepatocellular carcinoma pathogenesis: from genes to environment (2006, background): “An important recent advance has been the establishment of a cell-culture model supporting efficient HCV replication and infectious particle productio”
Evasion of intracellular host defence by hepatitis C virus (2005, background): “The recent development of cell-culture models of HCV infectio”
A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity (2014, methodology): “A plasmid of pFNX-HCV that carries the viral genome was synthesized in our lab based on the chimeric sequence of J6/JFH1 virus [13].”
Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis (2006, background): “A second major advance has been the recent development of a cell culture model for HCV (30, 56, 59).”
Flaviviridae :T he Viruses and Their Replication (2007, background): “Depending on the culture conditions and viral genetic factors, HCVcc grows to titers of approximately 105 infectious units/mL (407,562,811).”
The lipid droplet is an important organelle for hepatitis C virus production (2007, methodology): “To elucidate the mechanisms of virus production, we used a HCV strain, JFH1, which can produce infectious viruse”
Unravelling hepatitis C virus replication from genome to function (2005, background): “5 cells, which are highly permissive for HCV RNA replicatio”
Mechanism of action of interferon and ribavirin in treatment of hepatitis C (2005, background): “The recent description of a cell-culture system that allows complete HCV replication will probably provide tools to characterize more fully the mechanisms of antiviral activity of IFN and the means to assess new antiviral agent”