Imaging of Germinal Center Selection Events During Affinity Maturation

By Christopher D. C. Allen, T. Okada, H. L. Tang, J. Cyster. Science, 2007

820 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/de0913b205612ff1f6634d31f7c696902050f31f

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In Immunology

In Immunology and Allergy

Citations in the corpus

Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, positive): “…are necessary for GCmaintenance (Han et al., 1995a; Huntington et al., 2006), and that each of these signals is capable of extending B cell survival in vitro (Liu et al., 1989), evidence for one or the other as agents of selection in the GC is circumstantial (Allen et al., 2007a; Tarlinton, 2008).”
Germinal centres: role in B-cell physiology and malignancy (2008, background): “Indeed, proliferating B cells can be detected in the light zone of mouse splenic GC”
Follicular Helper T Cells. (2016, background): “GC B cells form dendrite-like structures or pseudopods, differing from the more rounded plasma cells and naive recirculating B cells (175, 176).”
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission (2008, background): “dtd" [ ]> Transmission of HIV-1 via intercellular connections has been estimated as 100–1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence of neutralizing antibodie”
The who, how and where of antigen presentation to B cells (2009, background): “Recently, three independent studies examining the spatio-temporal dynamics of B cells have questioned the original model and the absolute 'division of labour' between the two zones of the germinal centr”
Cytokine-secreting follicular T cells shape the antibody repertoire (2009, background): “Indeed, theoretical models and imaging experiments raise the possibility that T cell help could represent the most efficient mechanism for achieving the selection of high-affinity GC B cell”
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, methodology): “Adoptive T/B cotransfers and immunization of recipients were conducted, as previously described (21).”
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells (2007, background): “Furthermore, by 4 h after injection of phycoerythrin, follicular B cells had acquired a dendritic morphology reminiscent of that described for germinal center B cell”
Molecular mechanism and function of CD40/CD40L engagement in the immune system (2009, background): “tor 4 (CXCR4), is expressed on GC centroblasts (102, 103).”
Germinal-center organization and cellular dynamics. (2007, background): “…based on the long-recognized segregation of the GC structure from the surrounding follicular mantle, the imaging analysis showed that most GC B cells and follicular mantle B cells turned at the interface between the compartments and did not cross from one region into the other (Allen et al., 2007).”
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells (2010, background): “Follicular helper T cells (T FH cells), along with T cells at the T cell–B cell border, are a source of extrinsic factors that promote GC formation, expansion and isotype switchin”