Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

By T. Phan, I. Grigorova, T. Okada, J. Cyster. Nature Immunology, 2007

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The who, how and where of antigen presentation to B cells (2009, background): “Indeed, macrophage receptor 1 ( MAC1 ; also known as αMβ2 integrin and CD11b–CD18 dimer), which is a receptor for complement component 3 ( C3 ) that is expressed by macrophages, has been suggested to contribute to the retention of antigen on the cell surfac”
Germinal-center organization and cellular dynamics. (2007, background): “Follicular B cells might have a role in this transport process (Phan et al., 2007).”
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “By contrast, larger antigens, such as viruses and immune complexes , are initially captured by subcapsular sinus macrophages and subsequently shuttled to B cells, which transport the antigens to follicular DCs (FDCs) located in B cell follicle”
Follicular shuttling of marginal zone B cells facilitates antigen transport (2008, background): “Blood B cells were able to rapidly capture small amounts of injected Ficoll, and it has been shown that follicular B cells in lymph nodes capture and transport immune complexes to FDCs in a CD21-dependent wa”