CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

By S. Herzig, Fanxin Long, U. Jhala, S. Hedrick, Rebecca Quinn, A. Bauer, D. Rudolph, G. Schutz, Cliff Yoon, P. Puigserver and 2 more. Nature, 2001

1,471 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/ddb6dc4756572ec121c60bc2c138d081a3388c4a

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Citations in the corpus

SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Consistent with this role, increased expression of PGC-1 in the liver results in enhanced hepatic glucose production (135).”
Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “PGC-1 (now PGC-1a) expression is activated by the PKA–CREB pathway, which is downstream from the b-adrenergic receptor (Herzig et al. 2001).”
The role of FoxO in the regulation of metabolism (2008, background): “Insulin reduces the level of cyclic AMP generated in response to glucagon, resulting in an abrogation of cyclic AMP response element binding protein-dependent PGC1a transcription (Herzig et al., 2001).”
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. (2006, background): “CREB is activated upon glucagon signaling in the liver (22), whereas calcium signaling cascades converge on CREB in skeletal muscle (37).”
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “PGC-1a is induced in mouse liver upon fasting [7,8] and in C2C12 cells during differentiation [46].”
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “This increase in NAD content correlates with increased SIRT1mediated deacetylation and activation of the coactivator PGC-1 (82), which then promotes gluconeogenesis by coactivating a set of transcription factors, including hepatocyte nuclear factor-4 (104), glucocorticoid receptor (105), and FOXOs (”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “transcriptional expression of PGC-1 , which in turn serves as a coactivator of gluconeogenic gene expression (93).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Expression of ACREB has been successfully applied to analyze the function of CREB signaling in vivo (Herzig et al., 2001; Berdeaux et al., 2007).”
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, neutral): “PGC1a mRNA expression is sensitive to numerous signaling inputs that have been implicated in cancer biology (Herzig et al., 2001; Yoon et al., 2001; Chinsomboon et al., 2009; Arany et al., 2008).”