Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

By G. M. Guglielmo, C. Roy, Anne F. Goodfellow, Jeffrey L. Wrana. Nature Cell Biology, 2003

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Derailed endocytosis: an emerging feature of cancer (2008, background): “Notably, differential engagement of CME and CavME by the same receptor cargo (such as EGFR and transforming growth factor β (TGFβ) receptor) may regulate signalling capacity and endocytic fat”
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS (2005, background): “…endosomes through the interaction of the FYVE domain with the membrane lipid PtdIns(3)P. Complex formation of the receptors with SARA and Smad2/3 in early endosomes may thus be essential to efficiently initiate TGF-β signaling (Di Guglielmo et al. 2003, Hayes et al. 2002, Panopoulou et al. 2002).”
Smad transcription factors. (2005, background): “Activated TGF receptor complexes are also internalized via lipid rafts and caveolae, but this route is thought to lead to receptor interaction with the E3 ubiquitin ligase Smurf2 that targets the receptor for inactivation (Di Guglielmo et al. 2003).”