Rapid endo‐lysosomal escape of poly(DL‐lactide‐coglycolide) nanoparticles: implications for drug and gene delivery

By J. Panyam, Wencong Zhou, S. Prabha, S. Sahoo, V. Labhasetwar. The FASEB Journal, 2002

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Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines (2011, positive): “Nano-particles loaded with plasmid DNA could also serve as an efficient sustained release gene delivery system due to their rapid escape from the degradative endo-lysosomal compartment to the cytoplasmic compartment [56].”
Nanomedicine: current status and future prospects (2005, background): “For instance, nanoparticles made from poly(DL-lactide-co-glycolide) can escape the endo-lysosomal compartment within minutes of internalization in intact form and reach the cytoplasm (44).”
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “Trop J Pharm Res, April 2013;12 (2): 256 Zeta potential can affect the pharmacokinetic properties of nanosystems in the body [7,10] or may affect the phagocytosis of the nanoparticles in the blood stream [11-13].”
Drug delivery and nanoparticles: Applications and hazards (2008, background): “Poly(DL-lactide-co-glycolide) nanoparticles were found to be ingested by cells by endocytosis (Panyam et al 2002; Konan et al 2003).”
Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, background): “The susceptibility of these DNA nanostructures to premature nuclease degradation may limit their utility, but modified nucleic acids have proved much more stable [84, 85].”