Receptor downregulation and multivesicular-body sorting

By David J. Katzmann, G. Odorizzi, S. Emr. Nature reviews. Molecular cell biology, 2002

1,274 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0bb2853d03ac9dcaea87e2303bc4b229a69bda52

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In Cell Biology

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In Immunology

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In Molecular Biology

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Citations in the corpus

• Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. (2006, background): “…to receptor tyrosine kinases (RTK) in animals (Shiu and Bleecker 2001), mechanisms established for RTKs could also take place for RLKs. Attenuation of RTK signaling can be achieved by internalization of the receptors, either constitutively or selectively upon ligand binding (Katzmann et al. 2002).”
• β-Arrestins and Cell Signaling (2007, background): “Moreover, PalF phosphorylation and ubiquitination are crucial in linking receptor internalization to the multivesicular body–sorting pathway (42).”
• Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “Exosomes were shown to be sorted to larger compartments positive for the MVB marker TSG101 (tumor susceptibility gene 101 protein) (22) (Fig.”
• Biogenesis and function of multivesicular bodies. (2007, background): “Finally, ESCRT-II recruits ESCRT-III subunits, which can form a large polymer on the surface of endosomes (Katzmann et al. 2002, Raiborg et al. 2003).”
• The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins (2009, background): “In particular, the isolation of vacuolar protein sorting ( vps ) mutants in the yeast Saccharomyces cerevisiae has identified a conserved mechanism for ubiquitin-dependent sorting of membrane proteins from the limiting membranes into the ILVs of endosome”
• Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling (2003, background): “Ubi-quitination also serves as a signal for the sorting of endocytic c (cid:1) 2003 Biochemical Society cargo into appropriate vesicles that invaginate into multivesicular bodies which ultimately target the cargo to lysosomes (vacuole in case of yeast) for degradation [70].”
• Exosomes are released by cultured cortical neurones. (2006, background): “In contrast, NMDA leads to displacement of the endocytosed GluR2 towards MVBs (Lee et al., 2004).”
• Ubiquitylation and cell signaling (2005, background): “Importantly, two of the ESCRT-I subunits, TSG101 and hepatocellular carcinoma-related protein 1 (HCRP1), are linked to the development of tumors (Katzmann et al, 2002; Bache et al, 2004a).”