The pathobiology of vascular dementia

By C. Iadecola. Neuron, 2013

1,734 citations recorded by the source corpus.

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to full-blown dementia, attributable to cerebrovascular causes. Often coexisting with Alzheimer’s disease, mixed vascular and neurodegenerative dementia has emerged as the leading cause of age-related cognitive impairment. Central to the disease mechanism is the crucial role that cerebral blood vessels play in brain health, not only for the delivery of oxygen and nutrients, but also for the trophic signaling that links inextricably the well being of neurons and glia to that of cerebrovascular cells. This review will examine how vascular damage disrupts these vital homeostatic interactions, focusing on the hemispheric white matter, a region at heightened risk for vascular damage, and on the interplay between vascular factors and Alzheimer’s disease. Finally, preventative and therapeutic prospects will be examined, highlighting the importance of midlife vascular risk factor control in the prevention of late-life dementia.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/cda28e08e51b962067edb67f14120a3b4a61d234

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Citations in the corpus

Vascular dysfunction – the disregarded partner of Alzheimer’s disease (2019, positive): “…defined above, further inclusion of SVD features in the differential biological approach in sporadic AD, ADAD [65] and other dementias would be relatively easy to achieve and is highly relevant since SVD of the brain contributes to > 50% of all dementias worldwide including AD [19,66–69].”
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology (2014, background): “The pathophysiology of VaD has been critically reviewed recently [48,144-146].”
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus (2015, positive): “, 2011) that play a key role in maintaining the BBB integrity (Zlokovic, 2008, 2011; Iadecola, 2013; Daneman et al., 2010; Armulik et al., 2010; Bell et al., 2010, 2012; Winkler et al., 2012).”
Pericytes of the neurovascular unit: Key functions and signaling pathways (2016, background): “angiogenesis; (3) impaired phagocytosis causing CNS accumulation of neurotoxins; (4) CBF dysfunction and ischemic capillary obstruction; (5) increased”
Impact of Hypertension on Cognitive Function (2016, neutral): “tory mediators and reactive oxygen and nitrogen species, but conclusive evidence is lacking, especially in humans.(27)”