Central nervous system pericytes in health and disease

By E. Winkler, R. Bell, Berislav Zlokovic. Nature Neuroscience, 2011

922 citations recorded by the source corpus.

Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/abc7bfb4e409300e81891c363fe0a0b1040f2949

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In Cellular and Molecular Neuroscience

In Neurology

Citations in the corpus

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier (2015, positive): “A key event during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB) 1,2 , which consists of the endothelium and surrounding cells 3,4 .”
3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Moreover, HUVECs offer a poor model for cerebral vasculature, while PCs, recognized to be a key component of the BBB [35], have not been considered in these models [32,34].”
Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes (2015, neutral): “…tree, especially at the transition between arterioles and terminal capillaries, are the primary sites of CBF regulation remains a topic of debate (Armulik et al., 2011; Hamilton et al., 2010; Iadecola and Nedergaard , 2007; Itoh and Suzuki, 2012; Krueger and Bechmann, 2010; Winkler et al., 2011).”
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus (2015, positive): “PDGFRβ is an established marker of the BBBassociated pericytes (Armulik et al., 2010; Bell et al., 2010, 2012; Winkler et al., 2011 ) that play a key role in maintaining the BBB integrity (Zlokovic, 2008, 2011; Iadecola, 2013; Daneman et al., 2010; Armulik et al., 2010; Bell et al., 2010, 2012;…”
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity (2020, background): “Pericytes also play essential roles in maintaining BBB integrity, aiding in angiogenesis, and microvascular stability [30, 34].”
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, positive): “Altered association between pericytes and ECs has been shown in tumor vessels (Carmeliet and Jain, 2011; Winkler et al., 2011).”
Vascular Contributions to Cognitive Impairment and Dementia Including Alzheimer’s Disease (2014, background): “This manuscript summarizes the proceedings of this discussion.”
The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Normally, pericytes envelope the blood vessels of the CNS to aid in the control of blood flow, support angiogenesis, help maintain the blood-brain barrier, and perform other homeostatic functions (413).”
The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Pericytes play a key role in the regulation of angiogenesis, vascular remodeling, vascular tone, and BBB formation (Daneman et al., 2010a; Armulik et al., 2005, 2010; Winkler et al., 2011).”