The blood-brain barrier in health and chronic neurodegenerative disorders.

By Berislav Zlokovic. Neuron, 2008

3,223 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/89c5639e8037ea24b76a34c43c6c6c29765bacf7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. M. Sofroniew
2. M. Pekny
3. Berislav Zlokovic
4. M. Pekna
5. B. Barres
6. E. Hol
7. Alexei Verkhratsky
8. R. Bell

In Physiology

1. Berislav Zlokovic
2. D. Holtzman
3. B. Barres
4. A. Sagare
5. R. Bell
6. R. Daneman
7. R. Deane
8. N. Abbott

Citations in the corpus

• Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, neutral): “1) (Zlokovic 2008).”
• Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future (2023, background): “It has been identified that the expressions of the two blood efflux transporters LRP1 and ABCB1 were reduced during AD, whereas the expression of the blood influx transporter RAGE is elevated.(21,25) The perivascular drainage pathway plays a vital role in ISF bulk-flow clearance of Aβ.”
• VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown (2009, background): “T blood-brain barrier (BBB) acts as a selective interface separating the CNS parenchyma from the systemic circulation (1).”
• Central nervous system pericytes in health and disease (2011, background): “flow; and (5) provide clearance and phagocytotic functions in brain.”
• Structure and function of the blood-brain barrier. (2010, background): “…2007); hypoxia and ischemia (Kaur and Ling, 2008); edema (Rosenberg and Yang, 2007); Parkinson's disease and Alzheimer's disease (Desai et al., 2007; Zlokovic, 2008); epilepsy (Remy and Beck, 2006); tumours (Bronger et al., 2005); glaucoma (Grieshaber and Flammer, 2007) and lysosomal storage…”
• A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity (2020, background): “However, specific neuroactive peptides [135], regulatory proteins, hormones, and growth factors get the use of RMT systems to cross the BBB [136].”
• Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging (2010, background): “…factors in brain in vivo have not been demonstrated and that pericytes do not make direct contacts with neurons (in contrast to astrocytes) (Zlokovic, 2008), it is unclear at present whether pericyte degeneration can increase neuronal susceptibility to injury through diminished…”
• Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. (2012, background): “The BBB uses endothelial tight junctions to generate a physical barrier, allowing control of transcellular molecular trafficking via endothelial transporters and channels (1, 2).”