Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces

By S. Duncan, A. Belenguer, G. Holtrop, Alexandra M. Johnstone, H. Flint, G. Lobley. Applied and Environmental Microbiology, 2006

903 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/dd37a59ace2e7b13e455f2def7ac1d60cdb99d88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Nutrition and Dietetics

In Physiology

Citations in the corpus

Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects (2010, background): “) present in the human GIT can utilize this substrate in vitro, and various bacterial systems involved in the degradation of starch have been identified by genomic approaches [6,34,36,37,38,39,40,41,42,43].”
Intestinal microbiota in human health and disease: the impact of probiotics (2011, background): “…FISH GC Obese individuals on diet of decreased carbohydrate intake: ; Roseburia ; Eubacterium rectale subgroup of cluster XIVa ; bifidobacteria Duncan et al. (2007)* Faeces (2 time points) 18 Obese pregnant women 36 Normal-weight pregnant women FISH/flow cytometry qPCR Overweighed pregnant…”
Personalized Nutrition by Prediction of Glycemic Responses. (2015, background): “Notably, E. rectale can ferment dietary carbohydrates and fibers to produce metabolites useful to the host (Duncan et al., 2007), and was associated with improved postprandial glycemic and insulinemic responses (Martı́nez et al., 2013), as well as negatively associated with TIIDM (Qin et al., 2012).”
The role of pH in determining the species composition of the human colonic microbiota. (2009, positive): “Numbers of Roseburia spp. and E. rectale in faecal samples from obese male volunteers decreased fourfold, both in absolute number and as a proportion of total bacteria, after 4 weeks on a low carbohydrate weight loss diet (Duncan et al., 2007).”
Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. (2010, background): “Previous information on this group of bacteria has relied on anaerobic culturing allied to 16S rRNA-based molecular detection [e.g. (Barcenilla et al., 2000; Aminov et al., 2006; Duncan et al., 2007a)].”
Formation of propionate and butyrate by the human colonic microbiota. (2017, background): “…to a disproportionate decrease in butyrate among total faecal SCFA, together with an increased proportion of branched chain fatty acids that are wholly derived from branched chain amino acids and therefore provide an indicator of protein fermentation (Duncan et al., 2007, Russell et al., 2011).”
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla (2009, background): “The latter 2 datasets are composed of genes that are also up-regulated 10-fold relative to log-phase growth in minimal glucose medium (30).”
Unravelling the effects of the environment and host genotype on the gut microbiome (2011, background): “For example, changes in the dietry amounts of particular carbohydrates result in changes in population levels of the butyrate-producing Roseburia spp”
Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019, methodology): “Duncan [69] 2016 Humans 19 Experimental NA Two treatment groups: (1) high protein/medium carbohydrate (4weeks); (2) high protein/low carbohydrate (4 weeks).”
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. (2008, background): “A recent study explored the relationship between the representation of selected members of the Firmicutes and consumption of high and low carbohydrate diets in 19 obese volunteers over a 4 week period ( Duncan et al., 2007 ).”