Unravelling the effects of the environment and host genotype on the gut microbiome

By A. Spor, Omry Koren, Ruth E. Ley. Nature Reviews Microbiology, 2011

1,473 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e0ea1fae44cf3aa0c88b29417548445fb23a6e7d

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Citations in the corpus

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Intestinal dysbiosis, referring to “alterations in the composition and abundance of the gut microbiota as compared to healthy individuals” [153], is believed to account for inflammatory, metabolic diseases and even dysfunctions of central nervous system (Fig.”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Host genetic variation has been shown to be associated with variation in the microbiome composition, but genome-wide approaches to identify individual genes and their role in shaping the microbiome are only beginning to emerge (Blekhman et al., 2015; Spor et al., 2011).”
Associating microbiome composition with environmental covariates using generalized UniFrac distances (2012, background): “Received on February 15, 2012; revised on June 6, 2012; accepted on June 8, 2012”
The composition of the gut microbiota throughout life, with an emphasis on early life (2015, background): “It has been suggested that if the impact of host genotype on microbiota is less pronounced, detection of significant differences in healthy populations may require analysis of larger cohorts (67).”
Arsenic exposure and toxicology: a historical perspective. (2011, background): “Given the size and genetic diversity of organisms of the gut microbiome, it is probably not surprising that a complex interaction has evolved between these cells and cells that constitute the host component of the gastrointestinal system (Spor et al., 2011).”
Intestinal bacterial community structure differs between healthy and inflamed intestines in Atlantic salmon (Salmo salar L.) (2014, background): “The individual variation between fish with similar genetic background, raised in similar environmental conditions, and fed the same diet over a long time, probably represents an almost unexplored host influence on the bacterial diversity (McKnite et al., 2012; Navarrete et al., 2012; Spor et al., 20”
Host genetic variation impacts microbiome composition across human body sites (2015, neutral): “communities [23].”
Diet dominates host genotype in shaping the murine gut microbiota (2014, background): “, 2013), and numerous differences have been shown between transgenic animals and matched controls (Couturier-Maillard et al., 2013; Hashimoto et al., 2012; Spor et al., 2011).”
Host remodeling of the gut microbiome and metabolic changes during pregnancy. (2012, background): “The gut microbiota is shaped by environmental factors, such as diet (Wu et al., 2011), host genetics (Spor et al., 2011), and the immune system, which, in particular, can have profound effects on the composition of the gut microbiota (Salzman et al., 2010; Slack et al., 2009; Vijay-Kumar et al.,…”
The gut microbiota: a major player in the toxicity of environmental pollutants? (2016, background): “Hence, the combination of multiple factors including genotype, mode of delivery, early antibiotic therapy, diet composition, lifestyle, social interactions and environmental exposure to various xenobiotics shape the gut microbiota to make every individual microbially unique.(2,3) This is of importan”
Viral and Bacterial Interactions in the Upper Respiratory Tract (2013, background): “These bacterial communities evolve into a complex ecosystem during the first years of life, varying greatly among individuals and over time [8,9].”
The amphibian microbiome: natural range of variation, pathogenic dysbiosis, and role in conservation (2017, background): “…variation In order to disentangle ‘normal’ inter-individual variability in the gut and skin microbiome from disease-promoting disorders, the effects of extrinsic and intrinsic host variables on the natural range of microbiome variation have to be understood (Spor et al. 2011; Org et al. 2015).”