Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors.

By T. Loftus, D. E. Jaworsky, Gojeb L. Frehywot, C. Townsend, G. Ronnett, M. Lane, F. Kuhajda. Science, 2000

1,012 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/dc3e6cb0de10069f2d2699d3ae4044652d262db4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. D. Hardie
2. D. Moller
3. B. Kahn
4. Liangyou Rui
5. Haiming Cao

In Molecular Biology

1. D. Hardie
2. David Carling
3. T. Walther
4. Robert V Farese
5. B. Kahn
6. T. Alquier
7. D. Moller
8. Zhaohui Feng

In Physiology

1. D. Hardie
2. David Carling
3. T. Walther
4. Robert V Farese
5. D. Moller
6. B. Kahn
7. R. Zechner
8. P. Pacher

Citations in the corpus

• Fatty acid synthase and cancer: new application of an old pathway. (2006, neutral): “hepatocellular injury or fat necrosis (10).”
• New drug targets for type 2 diabetes and the metabolic syndrome (2001, background): “The prospect of a new approach to appetite reduction through central inhibition of fatty-acid synthase also offers an intriguing new avenue for drug research in this are”
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, background): “While some studies in which fatty acid synthase inhibitors were injected ICV in mice suggest that increases in hypothalamic malonyl CoA levels could act as anorexigenic signals (Hu et al., 2003; Loftus et al., 2000), this is controversial.”
• Central administration of oleic acid inhibits glucose production and food intake. (2002, background): “In this regard, the potential role of CNS lipid metabolism in the control of appetite is supported by the potent anorectic property of fatty acid synthase inhibitors (9,10).”
• Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. (2005, background): “The enzyme FAS is widely expressed in the brain, including in neurons of the hypothalamus linked to appetite control, and inhibitors of FAS dramatically reduce food intake, most likely by an action in the hypothalamus (21, 22, 25).”
• AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus (2004, result): “These results are also consistent with increased hypothalamic malonyl-CoA level”
• The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “In fact, inhibitors of fatty acid synthase are capable of greatly affecting appetite in an anorexigenic manner (303, 304).”
• Cellular Fatty Acid Metabolism and Cancer (2013, background): “In many reports, chemical inhibitors of FASN preferentially killed cancer cells (reviewed in Lupu and Menendez, 2006).”
• Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy (2008, background): “For treatment of viral infection by inhibiting fatty acid biosynthesis, targeting of ACC may be more clinically practical than targeting FAS, as FAS inhibition can cause severe anorexia and weight los”
• Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. (2004, background): “Since malonyl-CoA, the major physiological inhibitor of CPT1s, has been implicated in appetite control in mouse, (Loftus et al., 2000; Obici et al., 2003), it can be hypothesized that such a deficiency, if compatible with life, could present as an appetite dysregulation syndrom.”