Central administration of oleic acid inhibits glucose production and food intake.

By S. Obici, Zhaohui Feng, Kimyata Morgan, D. Stein, G. Karkanias, L. Rossetti. Diabetes, 2002

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Hypothalamic insulin signaling is required for inhibition of glucose production (2002, result): “In the presence of basal insulin levels, the ICV infusion of SU alone (either tolbutamide or glybenclamide) did not affect GP as compared with ICV vehicl”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Central infusion of oleic acid potently increases hepatic insulin sensitivity in rats (Obici et al. 2002b), and similar effects were noted after central infusion of an inhibitor of carnitine palmitoyltransferase-1 (CPT-1) (Obici et al.”
Energy Metabolism in the Liver (2014, neutral): “vagal nervous outflow to the liver (126,127, 195).”
Anatomy and regulation of the central melanocortin system (2005, background): “For example, intracerebroventricular admin–istration of oleic acid, a long-chain fatty acid, inhibits food intake and glucose productio”
Role of carnitine in disease (2010, background): “There is some debate in the literature regarding whether satiety depends on the cytosolic concentration of long-chain fatty acids, with the suggestion that an increased concentration correlates with satiety and decreased feeding and body weight [77-80].”