AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

By Y. Minokoshi, T. Alquier, N. Furukawa, Young-Bum Kim, Anna Lee, B. Xue, J. Mu, F. Foufelle, P. Ferré, M. Birnbaum and 2 more. Nature, 2004

1,690 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/8749d5c761be5f81471404446c21730824334183

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In Endocrine and Autonomic Systems

In Epidemiology

In Nutrition and Dietetics

Citations in the corpus

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, neutral): “The possibility that changes in AMPK activity can account for the food intake effects is strengthened by the fact that direct activation of hypothalamic AMPK increases food intake and body weight (Andersson et al., 2004; Minokoshi et al., 2004), while inhibition of hypothalamic AMPK decreases food i”
Mechanisms of leptin action and leptin resistance. (2008, background): “LRb stimulation mediates the tyrosine phosphorylation of IRS proteins and regulates the PI 3′-kinase pathway (74– 76) as well as the AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) pathways (77, 78), although the molecular mechanisms by which LRb regulates these pathways”
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript (Minokoshi et al., 2004).”
AMPK and PPARd Agonists Are Exercise Mimetics (2008, positive): “In mammals, AMPK has been shown to contribute to glucose homeostasis, appetite, and exercise physiology (Andersson et al., 2004; Hardie, 2007; Kubota et al., 2007; Mu et al., 2001; Minokoshi et al., 2004; Thomson et al., 2007).”
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. (2004, background): “For example, when energy availability is limited in rodents, AMPK functions to restore normal energy levels by stimulating glucose uptake in skeletal muscle and glycolysis in the heart and by promoting feeding by regulating a hypothalamic circuit (Marsin et al. 2000; Mu et al. 2001; Andersson et al.”