Failing to deactivate: resting functional abnormalities in autism.

By Daniel P. Kennedy, Elizabeth Redcay, Eric Courchesne. Proceedings of the National Academy of Sciences of the United States of America, 2006

596 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/dc20fe2c2ebb55984fde9622217997f3023caaaf

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Citations in the corpus

Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients (2010, methodology): “Our results mostly agree with other fMRI studies of DMN in ASD, generally showing decreased long-range (and not local) FC or activation of this network (Cherkassky et al., 2006; Kennedy and Courchesne, 2008a,b; Kennedy et al., 2006; Monk et al., 2009),”
Describing Inner Experience? Proponent Meets Skeptic (2011, background): “However, there is some variance to the rule: individuals with autism (Kennedy, 2006) and schizophrenia (Pomarol-Clotet et al.”
The Brain's Default Network (2008, methodology): “…is also disrupted in autism, schizophrenia, and Alzheimer’s disease, further encouraging one to consider how the functions of the default network might be important to understanding diseases of the mind (e.g., Lustig et al. 2003, Greicius et al. 2004, Kennedy et al. 2006, Bluhm et al. 2007).”
Great Expectations: Using Whole-Brain Computational Connectomics for Understanding Neuropsychiatric Disorders (2014, background): “…al., 2004; Supekar et al., 2008), post-traumatic stress disorder (Karl et al., 2006), dementia (Buckner et al., 2000; Rombouts et al., 2009), autism (Kennedy et al., 2006; Weng et al., 2010), multiple sclerosis (Bonavita et al., 2011), bipolar disorder (Lim et al., 2013) and major depression…”
Default-mode brain dysfunction in mental disorders: a systematic review. (2009, methodology): “In three versions of the Stroop task, adult autistic participants failed to show evidence of deactivation of the DMN, although there was little evidence of a difference in task performance between the groups (Kennedy et al., 2006).”
Frontocingulate Dysfunction in Depression: Towards Biomarkers of Treatment Response (2010, background): “…states associated with blunted resting rACC activity, including schizophrenia (Fletcher et al, 1998), dementia (Lustig et al, 2003), and autism (Kennedy et al, 2006), are characterized by reduced taskinduced rACC deactivation, although the possibility that this reflects a floor effect needs to…”
Transient and linearly graded deactivation of the human default-mode network by a visual detection task (2008, unknown): “It has also been shown thatDMNdeactivation ismodulated in clinical populations, such as those with an autistic-spectrum disorder (Kennedy et al., 2006), schizophrenia (Garrity et al., 2007; Harrison et al., 2007) and the elderly (Persson et al., 2007).”
The intrinsic functional organization of the brain is altered in autism (2008, background): “As previously suggested (Kennedy et al., 2006), this specificity may be related to the uniquely high metabolic activity of the TNN, which has been hypothesized to confer particular susceptibility to damage and dysfunction (Raichle et al.”
Reduced resting-state brain activity in the "default network" in normal aging. (2008, background): “The importance of studying RSNs in the context of clinical exploration has been illustrated by several studies (Greicius et al. 2004; Kennedy et al. 2006; Greicius et al. 2007), suggesting that analysis of intrinsic brain activity may enhance the understanding of disease.”
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics (2008, background): “Recent studies have already demonstrated that the brain DMN is disrupted in autism (Kennedy et al., 2006), Alzheimer’ disease (Greicius et al., 2004), depression (Greicius et al., 2007), schizophrenia (Liang et al., 2006; Williamson, 2007), and attention deficit hyperactivity disorder (Tian et al.,…”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “…treatment outcomes, including: Alzheimer's disease (Greicius et al., 2004; Lustig et al., 2003; Rombouts et al., 2005; Wang et al., 2006), autism (Kennedy et al., 2006), depression (Anand et al., 2005), multiple sclerosis (Lowe et al., 2002), and attention deficit/hyperactive disorder (ADHD;…”
Diffusion tensor imaging of the corpus callosum in Autism (2007, unknown): “The recently reported abnormalities of cingulate cortex deactivation may be relevant to our findings because if the cingulate cortex was damaged early in development, it could affect corpus callosum development (Kennedy et al., 2006; Rash and Richards, 2001).”
The Common Neural Basis of Autobiographical Memory, Prospection, Navigation, Theory of Mind, and the Default Mode: A Quantitative Meta-analysis (2009, unknown): “Rest Button press to flashing screen fMRI 13 22 older adults Kennedy, Redcay, & Courchesne ( 2006 ) Fixation Counting Stroop task fMRI 14 8 Mason et al.”
Functional connectivity of default mode network components: correlation, anticorrelation, and causality (2008, background): “To date, abnormalities in the DMN have been demonstrated in individuals with autism spectrum disorders [Kennedy et al., 2006], Alzheimer’s disease [Buckner et al.”