Frontocingulate Dysfunction in Depression: Towards Biomarkers of Treatment Response

By Diego A. Pizzagalli. Neuropsychopharmacology, 2010

929 citations recorded by the source corpus.

Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising predictor of treatment response in depression, but neither the reliability of this relationship nor the mechanisms supporting it have been thoroughly investigated. This review takes a three-pronged approach to these issues. First, I present a meta-analysis demonstrating that the relationship between resting rACC activity and treatment response is robust. Second, I propose that the rACC plays a key role in treatment outcome because of its ‘hub’ position in the default network. Specifically, I hypothesize that elevated resting rACC activity confers better treatment outcomes by fostering adaptive self-referential processing and by helping to recalibrate relationships between the default network and a ‘task-positive network’ that comprises dorsolateral prefrontal and dorsal cingulate regions implicated in cognitive control. Third, I support this hypothesis by reviewing neuropsychological, electrophysiological, and neuroimaging data on frontocingulate dysfunction in depression. The review ends with a discussion of the limitations of current work and future directions.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/121987ba85990fe31d0acd7046f6184cf8b5313d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Murat Yücel
2. Alex Fornito
3. E. Bora
4. Christos Pantelis
5. Olaf Sporns
6. D. Bassett
7. E. Bullmore
8. Yong He

In Experimental and Cognitive Psychology

1. Murat Yücel
2. Alex Fornito
3. E. Bora
4. Christos Pantelis

Citations in the corpus

• Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies. (2012, background): “Subgenual overactivity has been associated with depressive states and there is some evidence that treatment ameliorates this hyperactivity (Drevets et al., 2008; Mayberg, 1997, 2003; Pizzagalli, 2011).”
• COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS (2013, background): “[41] Progress in molecular and cellular biology as well as results from neuroimaging investigations have served to refine the hypothesis that disparate domains of psychopathology in MDD are subserved by abnormalities in the structure, function, and chemical composition of fronto-subcortical circuitr”
• A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression (2012, neutral): “, 2002; Drevets, 2001) with high relevance for treatment response (Mayberg, 1997, 2003; Pizzagalli, 2011) in depressed individuals.”