Towards a molecular understanding of adaptive thermogenesis

By Bradford B. Lowell, B. Spiegelman. Nature, 2000

1,618 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/dbd0f75f03f42784f5f5356050e68ff993831eca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. B. Spiegelman
2. Gerald I. Shulman
3. Johan Auwerx
4. L. Guarente
5. Jiandie D. Lin
6. P. Seale
7. E. Verdin
8. S. Kajimura

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. Johan Auwerx
4. P. Seale
5. E. Verdin
6. Jiandie D. Lin
7. M. Haigis
8. J. Nedergaard

Citations in the corpus

• Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. (2013, neutral): “However, of the major adipose tissue depots, only brown adipose tissue (BAT) is inversely correlated with BMI in humans (2, 3), and it consumes large amounts of energy for thermogenesis (4).”
• Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, positive): “This rapid increase in heat production, which occurs within seconds to minutes, is mediated by several thermoeffectors, including cutaneous vasoconstriction, skeletal muscle shivering, and UCP1-mediated respiration in brown adipocytes; processes that are all activated by the sympathetic nervous syst”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “Hence, it protects the organism from cold exposure and regulates energy balance after dietary changes (183).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “This futile cycle of proton pump and leak reduces mitochondrial membrane potential, which in turn drives high levels of substrate oxidation and results in the generation of heat (Cannon and Nedergaard, 2004; Lowell and Spiegelman, 2000).”
• Molecular and cellular endocrinology (2000, positive): “Therefore, it was evaluated the effect of yerba maté treatment on mRNA levels of genes involved whole body energy expenditure such as PGC-1˛ (Argilés et al., 2002) and UCP1 (Lowell and Spiegelman, 2000).”
• Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, background): “The most compelling case is made that upregulation of UCP2 and 3 in adipose tissue and muscle respectively may contribute in some way to appetite and weight regulation on the one hand (see Clapham et al., 2000; Lowell and Spiegelman, 2000) and also that UCP expression may help to limit the rate of f”