Cell biology: Autophagy and cancer

By Beth Levine. Nature, 2007

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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity (2010, background): “The autophagic process has also been associated with the inhibition of tumour developmen”
Toll‐like receptors control autophagy (2008, background): “effect on a wide range of normal physiological processes, including ageing and diseases such as cancer (Levine, 2007) and neurodegeneration (Alzheimer’s, Huntington’s and Parkinson’s diseases and ataxias; Rubinsztein, 2006).”
Emerging roles of proteases in tumour suppression (2007, result): “This process was originally described as a physiological response to starvation, but recent studies have also shown its relevance in cance”
Autophagy: process and function. (2007, background): “For example, although autophagy is generally considered to be a tumor-suppressive process (Hippert et al. 2006; Levine 2007), the relationship between autophagy and cancer is complicated, in part because different steps of autophagy have different roles in tumor generation and tumor survival .”
Autophagy in the pathogenesis of disease. (2008, unknown): “In the past decade, several genetic links have emerged between autophagy defects and cancer, providing increasing support for the concept that autophagy is a bona fide tumor suppressor pathway (Levine, 2007; Mathew et al., 2007a).”
BCL-2 family antagonists for cancer therapy (2008, background): “, and although its role in tumour suppression has been suggeste”