Emerging roles of proteases in tumour suppression

By C. López‐Otín, L. Matrisian. Nature Reviews. Cancer, 2007

826 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/154aee3278a145ccfc7f04b0521f1fdc6024a1a3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zena Werb
2. Hideaki Nagase
3. V. Plaks
4. K. Kessenbrock
5. D. Edwards
6. D. Lyden
7. Guido Kroemer
8. B. Psaila

In Hematology

1. Hideaki Nagase
2. Zena Werb
3. V. Plaks
4. D. Lyden
5. D. Edwards
6. Gillian Murphy

In Oncology

1. Zena Werb
2. V. Plaks
3. D. Edwards
4. Hideaki Nagase
5. K. Kessenbrock
6. Guido Kroemer
7. B. Psaila
8. D. Lyden

Citations in the corpus

• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “The tumor-suppressing functions of these MMPs is probably another reason for the failure of broad-spectrum MPIs as anticancer drugs (Lopez-Otin and Matrisian, 2007).”
• The metastatic niche: adapting the foreign soil (2009, background): “MMPs are instrumental in degrading ECM components during inflammatory responses and tissue repair as well as in primary tumour growt”
• Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15 (2015, background): “Also ADAMTS1 is among several ADAMTS genes that are epigenetically silenced in many types of cancer suggesting its function as a tumor-suppressor.(1,29) How then can we rationalize this apparent duality? The ADAMTS enzymes are ECM-binding proteases whose substrates include integral matrix components”
• Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis (2010, positive): “Recently, the generation of animal models involving gain or loss of function of matrix metalloproteinases (MMPs) has led to the surprising discovery of tumor-suppressive function for some proteases (Lopez-Otin and Matrisian, 2007).”
• Lysosomal membrane permeabilization in cell death (2008, background): “In addition to these tumor-promoting effects of cathepsins, evidence is emerging that proteases, and in particular cathepsins, may have a function as tumor suppressors as well (Lopez-Otin and Matrisian, 2007).”
• The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family (2015, background): “For many family members, the dominant theme is tumor suppression as they show epigenetic silencing (ADAMTS1, 8, 9, 12 and 18) or mutational inactivation (ADAMTS15) in several cancer types [48, 51, 108–114].”