Autophagy in the pathogenesis of disease.

By Beth Levine, Guido Kroemer. Cell, 2008

7,098 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0da89efc1604f775690a30974583afc45ff86bdb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

Citations in the corpus

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity (2013, methodology): “Animals were also tested for forelimb akinesia using the stepping test as described previously (1).”
Autophagy Failure in Alzheimer's Disease – Locating the Primary Defect (2011, background): “The inhibition of mTOR sets in motion a sequence of events coordinated by complexes of autophagy-related (Atg) proteins that initiate the formation of the autophagosome (Diaz-Troya et al., 2008; Levine and Kroemer, 2008).”
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (2009, background): “Macroautophagy (simply referred to as autophagy hereafter) is a major degradation system, by which cytoplasmic contents are degraded in the lysosomes (Klionsky, 2007; Mizushima, 2007; Levine and Kroemer, 2008; Mizushima et al., 2008).”
The BCL-2 Family Reunion (2010, background): “Autophagy is a process in which cytoplasm is engulfed by a double-layered membrane structure which then fuses with lysosomes (referred to as an autolysosome), promoting the degradation of its contents (reviewed in Levine and Kroemer, 2008).”
ER stress-induced cell death mechanisms. (2013, background): “Given that autophagy has been linked to protection from several diseases (neurodegeneration, diabetes, infectious diseases) and to promotion of some (cancer) (reviewed in [64]) the linkages between ER stress and autophagy may have relevance to several diseases.”
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. (2008, background): “Other studies revealed important roles for auto- phagy in eradication of microbes, antigen presentation, tumor suppression (Levine and Kroemer, 2008), and endoplasmic retic- ulum (ER) stress responses (Yorimitsu et al., 2006; Ogata et al., 2006).”
Role of nrf2 in oxidative stress and toxicity. (2013, background): “Macroautophagy is a conserved bulk protein degradation pathway responsible for the turnover of long-lived proteins, disposal of excess or damaged organelles, and clearance of aggregation-prone proteins (86).”
The Double-edged Sword of Autophagy Modulation in Cancer (2009, background): “by stress, including starvation, hypoxia, and factor deprivation (2, 10).”
Autophagy and autophagy-related proteins in cancer (2020, background): “The spontaneous frequency of malignancies is higher in the Beclin1 mouse model [192, 193], indicating that autophagy is a tumorsuppression mechanism [11, 25, 190, 194].”
Autophagy and aging. (2011, background): “Autophagy in dying cells is required for optimal macrophage-mediated clearing of apoptotic corpses, thus reducing inflammatory reactions (Levine and Kroemer, 2008).”
Autophagy and multidrug resistance in cancer (2017, background): “Autophagy is also closely related to the development of many diseases, including Alzheimer’s disease, cancer, and microorganism infection [3, 4].”
The dynamic nature of autophagy in cancer. (2011, background): “…(referred to hereafter as autophagy) is a regulated and evolutionarily conserved catabolic process that serves to degrade these structures and recycle their biochemical components for use in energy production and other biosynthetic reactions (Levine and Kroemer 2008; Yang and Klionsky 2010b).”