Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria.

By B. Antonsson, S. Montessuit, Sandra Lauper, Robert Eskes, J. Martinou. Biochemical Journal, 2000

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c (2000, background): “The subsequent release of larger proteins, such as sulfite oxidase, suggests that further oligomerization of BAX in vivo or secondary effects may follow.(56) Based on the data here, we hypothesize that the BAX or BAK mediated release of cytochrome c from mitochondria requires the establishment of a ”
Cellular and molecular mechanisms of mitochondrial function (2012, background): “75 The mechanism that triggers Bax associationwith the mitochondrial surface in healthy cells”
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death (2007, background): “Indeed, Bax and Bak can form cytochrome c-permeant channels in the absence of other proteins (22).”