Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

By S. Korsmeyer, M. Wei, M. Saito, S. Weiler, K. J. Oh, P. Schlesinger. Cell Death and Differentiation, 2000

1,074 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/801a67a8a2aa4dc051bc0ac7f00890a962133d3c

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In Molecular Biology

1. Douglas R. Green
2. X. Wang
3. K. Yip
4. F. Llambi
5. John Calvin Reed
6. Fenghe Du
7. M. Duchen
8. Xiaodong Wang

In Oncology

1. M. Duchen
2. John Calvin Reed
3. Douglas R. Green
4. X. Wang
5. F. Llambi

Citations in the corpus

• The Role of Resveratrol in Cancer Therapy (2017, background): “For instance, Fas is connected to the intrinsic pathway that is regulated via the activation of caspase-8 to cause cleavage of the BID protein, causing cytochrome c to be released from the mitochondria [102,103].”
• Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. (2003, background): “Activated BH3-only proteins induce the formation of mitochondrial oligomeric Bax/Bak complexes either directly or indirectly by binding and inactivating antiapoptotic Bcl-2 family members (Korsmeyer et al. 2000; Letai et al. 2002).”
• Bcl-2 family proteins and cancer (2008, background): “A prominent example utilized by TNFfamily death receptors involves caspase-mediated cleavage and activation of Bid, which then targets mitochondrial membranes where it binds Bcl-2/Baxfamily proteins and modulates their activities (Korsmeyer et al., 2000).”
• Cell Death Signaling. (2015, background): “Upon activation, they form large oligomers that insert into the mitochondrial outer membrane, disrupting it (Eskes et al. 2000; Korsmeyer et al. 2000; Dewson et al. 2008, 2009).”
• Cellular and molecular mechanisms of mitochondrial function (2012, background): “71 In viable mammalian cells Bax is located in the cytosol with small amounts loosely associated with themitochondrial surface.”
• The expanding role of mitochondria in apoptosis. (2001, background): “The proapoptotic members of the Bcl-2 family that contain BH1–BH3 but not BH4, such as Bax and Bak, are the likely mediators for the BH3-only proteins (Korsmeyer et al. 2000).”