Life in the balance: how BH3-only proteins induce apoptosis.

By Simon N. Willis, Jerry M. Adams. Current Opinion in Cell Biology, 2005

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The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “The Bcl-2 apoptotic switch in cancer development and therapy JM Adams and S Cory”
Hypoxia-induced autophagy: cell death or cell survival? (2010, background): “Several studies previously characterized BNIP3, a BH3-only protein, as a proapoptotic protein [3].”
Hallmarks of cancer: the next generation. (2011, positive): “…contains a single such BH3 motif, are coupled to a variety of sensors of cellular abnormality; these ‘‘BH3-only’’ proteins act either by interfering with antiapoptotic Bcl-2 proteins or by directly stimulating the proapoptotic members of this family (Adams and Cory, 2007; Willis and Adams, 2005).”
The TRAIL apoptotic pathway in cancer onset, progression and therapy (2008, background): “Cleaved BID (tBID) activates the intrinsic apoptotic pathway by binding to BAX , Bcl2-homologous antagonist/killer ( BAK ) or pro-survival Bcl2 family protein”
Anticancer activities of histone deacetylase inhibitors (2006, background): “BH3-only BCL2 family proteins regulate activation of the intrinsic apoptotic pathway through direct interactions with pro-apoptotic proteins (Bax and Bak) or pro-survival BCL2 family proteins (BCL2, BCL-X L , MCL1 , BCL-w and A1”
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains (2009, background): “teins (40) that heterodimerize and antagonize the activity of”