Defining the Epithelial Stem Cell Niche in Skin

By T. Tumbar, Géraldine Guasch, V. Greco, C. Blanpain, W. Lowry, Michael Rendl, Elaine Fuchs. 2004

2,067 citations recorded by the source corpus.

Subfields: Cell Biology, Rehabilitation, Urology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Elaine Fuchs
2. Hans Clevers
3. C. Blanpain
4. H. Pasolli
5. S. Morrison
6. V. Horsley
7. R. Nusse
8. Linheng Li

In Rehabilitation

1. Elaine Fuchs
2. H. Pasolli
3. C. Blanpain
4. Hans Clevers
5. Y. Hsu
6. V. Horsley
7. N. Stokes
8. S. Werner

In Urology

1. Elaine Fuchs
2. Hans Clevers
3. C. Blanpain
4. H. Pasolli
5. R. Nusse
6. Linheng Li
7. V. Horsley
8. Y. Hsu

Citations in the corpus

• A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration (2009, positive): “…in neonatal and adult mice, bulge cells are typified by certain key SC markers including Sox9, Lhx2, NFATc1, Tcf3, and Lgr5 (Merrill et al., 2001; Tumbar et al., 2004; Morris et al., 2004; Blanpain et al., 2004; Rhee et al., 2006; Vidal et al., 2005; Nguyen et al., 2006; Horsley et al., 2008;…”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “…et al., page 559 of this issue), epithelial stem cells reside within the bulge of hair follicles (Cotsarelis et al., 1990; Taylor et al., 2000; Tumbar et al., 2004), neural stem cells reside within the lateral ventricle subventricular zone of the central nervous system (Doetsch, 2003; see…”
• Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. (2010, methodology): “S phase label retention has been used to identify stem cells with prolonged cell cycle reentry times and is often referred to as a stem cell characteristic (Cotsarelis et al., 1990; Tumbar et al., 2004; Zhang et al., 2003).”
• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…are only important for tumor initiation and are less critical for tumor progression will require a genetic strategy, similar to that used to monitor skin stem cells in vivo using a doxycyline-in-ducible H2B-eGFP reporter tag that enabled selection of CD133 + cells over time (Tumbar et al. 2004).”
• Epidermal stem cells of the skin. (2006, background): “In all three of these methods for obtaining bulge cells with high purity, bulge cells form large colonies that can be passaged in vitro (Morris et al. 2004, Tumbar et al. 2004).”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Mice The transgenic mouse line that expresses the fusion protein histone H2Bgreen fluorescent protein (H2B-GFP) under the control of a tetracyclineresponsive regulatory element (Tumbar et al., 2004) was purchased from Jackson Laboratories (Bar Harbor, ME).”
• Wnt signaling in development and tissue homeostasis (2018, background): “, 2014) and cells from the bulge migrate to the base of the hair follicle and begin proliferating rapidly to produce cell lineages of a new hair follicle (Oshima et al., 2001; Tumbar et al., 2004).”
• Characterization and isolation of stem cell-enriched human hair follicle bulge cells. (2005, methodology): “Accumulated evidence subsequently confirmed that, in rodents, the bulge is the repository of multipotent stem cells that support hair follicle cycling and repopulate interfollicular epidermis and sebaceous epithelium (6, 7, 9–11).”
• Growth and regeneration of adult beta cells does not involve specialized progenitors. (2007, result): “Consistent with this finding, the bulge of the outer root sheath has been observed to contain stem cells and their immediate progeny (Cotsarelis et al., 1990; Tumbar et al., 2004).”
• The intestinal stem cell. (2008, methodology): “An elegant variation of this strategy involves the use of Histone-GFP marking (Tumbar et al. 2004).”