A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules.

By N. Fernandez, Emmanuel Treiner, R. Vance, Amanda M. Jamieson, S. Lemieux, D. Raulet. Blood, 2005

634 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/da150c4e61868ead255462649c40ffa7cda1d3fa

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In Immunology

Citations in the corpus

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, result): “This model is consistent with recent studies implicating inhibitory receptors for MHC class I in the education and eventual killing capacity of NK cell”
Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. (2014, positive): “Furthermore, the inflammatory state accompanying infections with Listeria monocytogenes increased the responsiveness of hyporesponsive NK subsets in normal mice (18).”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “However, there exists a relatively small population of NK cells that do not express selfreactive inhibitory receptors under normal conditions, and these cells are hypofunctional upon stimulation (89).”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “NK cells that lack ITIM-bearing inhibitory receptors for self-MHC-I and NK cells from hosts that lack MHC-I ligands for ITIM-bearing inhibitory receptors have a reduced responsiveness to activation signals, such as cross-linking of an activation receptor or stimulation by sensitive target cells (5, ”
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “These subsets of NK cell are non-responsive to several activating receptor stimulations in vitro and fail to reject MHC class I-deficient bone marrow cells in vivo (111, 112).”
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, methodology): “Irradiated Klrk1 +/+ or Klrk1 À/À B6 mice were challenged with class I-deficient (B2m À/À ), B6 strain bone marrow cells, mixed in the same inoculum with wild-type bone marrow cells that served as an internal negative control (Fernandez et al., 2005).”
Self-tolerance of natural killer cells (2006, background): “A key focus of the Review is on recent studies from two laboratories that show that some NK cells are tolerant to self despite lacking inhibitory receptors specific for self MHC class I molecule”
Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “…demonstrating that NK cells undergo an education process that has been compared by some to ‘‘positive selection’’ of T cells (Anfossi et al., 2006; Fernandez et al., 2005; Kim et al., 2005), and a recent report indicating that NK cells are capable of immunological ‘‘memory’’ (O’Leary et al.,…”
Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “Furthermore, a subpopulation of NK cells that lack known inhibitory receptors for self-MHC class I exists in normal mice, but this population displays reduced responsiveness relative to NK cells expressing inhibitory receptors (40).”
Functions of natural killer cells (2008, background): “This education process requires the recognition of self–MHC class I molecules by cognate inhibitory receptors, such as Ly49 molecules in mice and KIRs in human”