Self-tolerance of natural killer cells

By D. Raulet, R. Vance. Nature reviews. Immunology, 2006

640 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/f4ff37f841aeb2d39c17a0cb54f8c3010134561d

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In Immunology

1. É. Vivier
2. S. Ugolini
3. A. Steinle
4. I. Waldhauer
5. Peter Parham
6. Christoph Borner
7. M. Peterson
8. Chao Yang

Citations in the corpus

• The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation (2012, background): “…that Eomes and Eomes+ NK cells expressed NKG2A (Figure S5E) and Ly49C and/or Ly49I (Figure 1F), which bind MHC class I ligands in C57BL/6 mice (Brennan et al., 1996a, 1996b; Liu et al., 2000) and arm or license NK cells to kill targets (Kim et al., 2005; Raulet and Vance, 2006; Vance et al., 1998).”
• Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “A similar model, called disarming, has been proposed to explain how NK cells devoid of an inhibitory receptor for self-MHC are unresponsive, even in the presence of MHC-I (Figure 4) (187, 189).”
• NK cells and cancer immunosurveillance (2008, background): “Most NK cells express at least one inhibitory receptor that is believed to be randomly expressed from a pool of inhibitory receptor genes (Raulet and Vance, 2006; Yokoyama and Kim, 2006).”
• Functions of natural killer cells (2008, background): “This education process requires the recognition of self–MHC class I molecules by cognate inhibitory receptors, such as Ly49 molecules in mice and KIRs in human”
• Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, result): “Notably, this concept of greater inhibition during NK cell development ultimately leading to more vigorous activation under appropriate conditions, such as viral infection, is consistent with data implying inhibitory receptor involvement in the developmental regulation of NK cell responsivenes”
• Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “The “disarming” model proposes that chronic stimulation of NK cells that lack self-MHC-I inhibitory receptors are rendered hyporesponsive to stimulatory receptor activation potentially through a process similar to anergy in T or B cells (91).”
• Senescence of activated stellate cells limits liver fibrosis (2008, background): “NK cells are a major component of the innate immune system that recognize tumors, viruses, and MHC mismatched bone marrow grafts (Raulet and Vance, 2006).”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “Conversely, cells expressing ligands for killing stimulatory/activating receptors such as the NKG2D are targeted for cytolysis (Raulet and Vance 2006).”