Functions of natural killer cells

By É. Vivier, E. Tomasello, M. Baratin, T. Walzer, S. Ugolini. Nature Immunology, 2008

3,827 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/25da9b199edde64037499489383fe4f4199460f3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “Natural killer (NK) cells are lymphocytes of the innate immune system that produce proinflammatory cytokines (such as interferon-γ (IFN-γ)) and mediate cellular cytotoxicit”
Pre-activation with IL-12, IL-15, and IL-18 induces CD25 and a functional high affinity IL-2 receptor on human cytokine-induced memory-like NK cells (2014, background): “INTRODUCTION Natural killer (NK) cells are a subset of innate lymphoid cells critical for host antiviral defense andmediate antitumor immunity [1-5].”
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway (2016, background): “NK cells have the ability to kill other cells that are recognized as targets through an arsenal of receptors that recognize major histocompatibility complex (MHC) class I molecules or various surface ligands associated with cellular stress (1).”
Major Histocompatibility Complex Genomics and Human Disease (2013, neutral): “Engagement of these receptors by intact class I molecules inhibits further action, but if class I is missing, as in some viral infections and tumors, then activation takes place, leading to cytokine production and in some cases the death of the target (125).”
Maturation of mouse NK cells is a 4-stage developmental program. (2009, methodology): “(2) In a second phase (days 7-10), DP NK cells predominated in NK cells from all organs; and (3) in the later phase of the kinetics (days 14-28), CD27low NK cells progressively represented the majority of the cells, especially in the spleen, liver, and PBMCs.”
Targeting natural killer cells in cancer immunotherapy (2016, background): “13 Soluble activating NKG2D ligand 10 CD137 agonistic aptamer11 OX40 agonistic aptamer Not developed yet Preclinical development Tumor cell NK cell Stabilization of the immunological synapse Activation signals CD16 OX40 CD137 NKG2D Perforin, granzymes CD27 CD137 OX40 GITR IL-15R CD226 1 5 6 9 7 NKG2”
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “gr an zy m es A ut oi m m un ity [ 5 6, 1 51 , 1 52 ]”
Cytokine activation induces human memory-like NK cells. (2012, methodology): “We focused on the IL-12 pathway because: (1) IL-12 IL-18 was sufficient to induce mouse memory-like NK cell generation, (2) recent data in memory NK cells during MCMV identified IL-12 as a requisite signal during that model viral infection, and (3) our own restimulation conditions extensively used I”
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. (2016, background): “CD56brightCD16– NK cells can also differentiate into CD56dimCD16+ NK cells under appropriate conditions (55, 57).”