Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release.

By J. Whitfield, S. Neame, L. Paquet, O. Bernard, J. Ham. Neuron, 2001

596 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/da005f85dd3fcf9ef1cc0e0d6f4d28dc2151a74b

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In Cellular and Molecular Neuroscience

1. A. Strasser

In Molecular Biology

1. Jerry M. Adams
2. Suzanne Cory
3. A. Strasser
4. E. Wagner
5. R. Eferl
6. D. Huang
7. E. Shaulian
8. M. Karin

Citations in the corpus

• AP-1: a double-edged sword in tumorigenesis (2003, background): “In neuronal cells, c-Jun regulates the expression of Bim, a pro-apoptotic BCL2 FAMILY member that is crucial for neuronal apoptosi”
• FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons (2003, methodology): “FOXO activity contributes to NGF withdrawal–induced death Because BIM expression contributes to NGF withdrawal– induced death (Putcha et al., 2001; Whitfield et al., 2001) and the FKHRL1(A3)-induced death of sympathetic neurons (Fig.”
• Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins (2002, background): “Interestingly, in NGF-deprived neurons apparently only one isoform of Bim, BimEL, is upregulated.(42,43) Since all three isoforms of Bim (BimEL, BimL and BimS) are synthesised from the same transcript, 51 preponderance of the BimEL form may represent an additional level of regulation at the level of”
• The role of BH3-only proteins in the immune system (2005, background): “or through transcriptional induction by the JNK-activated transcription factor JUN (also known as AP1”
• The expanding role of mitochondria in apoptosis. (2001, background): “Dominant-negative c-Jun is also able to block Bim upregulation after NGF withdrawal in cultured neurons, suggesting that c-Jun may also participate in the transcriptional regulation of Bim (Whitfield et al. 2001).”
• The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “In neuronal cells, induction of bim following cytokine deprivation instead requires JNK activation (Harris and Johnson, 2001; Putcha et al., 2001; Whitfield et al., 2001).”
• AP-1 as a regulator of cell life and death (2002, background): “Similarly, inhibition of c-Jun activity through the expression of a dominant negative c-Jun mutant or injection of neutralizing antibodies, can protect neuronal cells from apoptosis induced by withdrawal of nerve growth factor (NGF) or chronic depolarizatio”