The role of BH3-only proteins in the immune system

By A. Strasser. Nature reviews. Immunology, 2005

686 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bd6aa313f6d586d1dec587fbb804bc71bdc7561e

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In Immunology

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Citations in the corpus

The many roles of FAS receptor signaling in the immune system (2009, positive): “During both B as well as T lymphopoiesis in primary lymphoid organs, apoptosis plays a critical role in the killing of cells that are either ‘‘useless’’ or ‘‘potentially dangerous’’ (Strasser, 2005).”
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells (2007, background): “Moreover, many apoptotic Bcl-2 members functionally cooperate in triggering the mitochondrial cell death pathwa”
Multiple Functions of BCL-2 Family Proteins (2013, background): “, tBID, BIM, and PUMA), or they promote death indirectly by inserting their BH3-containing helix into a hydrophobic groove on specific antiapoptotic BCL-2 proteins (Petros et al. 2000; Strasser 2005; Deng et al. 2007; Billen et al. 2008).”
Life in the balance: how BH3-only proteins induce apoptosis. (2005, background): “As reviewed further elsewhere [9 ], gene disruption is clarifying the physiological functions of BH3-only proteins.”
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis (2006, background): “This type of mechanism has been described for some BH3-only proteins that inactivate Bcl-2-like survival proteins, which keep cells alive by inactivating Bax–Bak-like protein”
Bcl-2 family proteins and cancer (2008, background): “Many proapoptotic proteins share sequence homology only in the BH3 domain (‘BH3only’ proteins), including Bid, Bim, Hrk, Bik, Puma, Noxa, Bcl-GS, Bmf and possibly Spike (reviewed by Strasser, 2005) (Figure 2).”
BCL-2 family antagonists for cancer therapy (2008, background): “By contrast, BIM, in addition to its major role in haematopoietic homeostasi”
Caspase-independent cell death (2005, background): “In addition, a subset of Bcl-2 family proteins, the BH3-only proteins, seem to be particularly important triggers of MOMP in a variety of pathway”
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “For example, loss of a single allele of Bim was shown to accelerate B-cell lymphomagenesis induced by expression of a c-myc transgene (Egle et al., 2004), in line with the key role of Bim as a regulator of lymphoid homeostasis (Strasser, 2005).”
The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “As reviewed recently (Strasser, 2005), Bim is a principal regulator of hematopoietic homeostasis, particularly in the lymphoid compartment (Bouillet et al., 1999).”