The Bcl-2 family: roles in cell survival and oncogenesis

By Suzanne Cory, D. Huang, Jerry M. Adams. Oncogene, 2003

1,528 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e6d1820e9763a7f54a130105205785524b8f98a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Jerry M. Adams
2. K. Yip
3. John Calvin Reed
4. P. Chiarugi
5. E. Giannoni

In Molecular Biology

1. Jerry M. Adams
2. Suzanne Cory
3. Simon N. Willis
4. P. Murphy
5. Leigh-Ann MacFarlane
6. D. Huang
7. K. Yip
8. P. Czabotar

In Oncology

1. Jerry M. Adams
2. Suzanne Cory
3. Simon N. Willis
4. P. Murphy
5. Leigh-Ann MacFarlane
6. John Calvin Reed
7. P. Chiarugi
8. P. Czabotar

Citations in the corpus

• Ways of dying: multiple pathways to apoptosis. (2003, background): “2003) Premature activity of the BH3-only proteins is precluded by diverse mechanisms (Bouillet and Strasser 2002; Puthalakath and Strasser 2002; Cory et al. 2003).”
• The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “There is now great interest in the prospect of developing drugs that mimic the action of the BH3 domain by binding to one or more of the Bcl-2-like proteins and triggering the apoptotic program (Cory et al., 2003; Fesik, 2005).”
• MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “BCL2 functions to block apoptosis by inhibiting mitochondrial cytochrome C release necessary to activate the caspase pathway of enzymes responsible for directing programmed cell death [268, 269].”
• Anoikis: an emerging hallmark in health and diseases (2012, background): “Bcl-2 is the master anti-apoptotic member of the family, and prevents apoptosis by maintaining mitochondrial membrane integrity [3,16,24,25].”
• Life in the balance: how BH3-only proteins induce apoptosis. (2005, background): “Just as Bcl-2 and its homologs are well-recognized oncoproteins [1 ,60], their BH3-only antagonists can act as tumor suppressors.”
• The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (2006, background): “, 2005), the compound might have been expected to induce toxic effects in vivo related to some of the developmental defects in mice lacking each of those proteins (Cory et al., 2003; Ranger et al., 2001).”
• Bcl-2 family proteins and cancer (2008, background): “Bcl-2-family proteins play central roles in cell death regulation and are capable of regulating diverse cell death mechanisms that encompass apoptosis, necrosis and autophagy (Cory et al., 2003; Levine and Kroemer, 2008; Reed, 2008).”
• Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. (2005, background): “Since BH3-only proteins are key initiators of apoptosis, there is growing interest in developing drugs that kill tumor cells by mimicking their inactivation of prosurvival targets (Cory et al. 2003).”