Hypoxia-Inducible Factor 1 (HIF-1) Pathway

By G. Semenza. Science's STKE, 2007

951 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Genetics

View Paper: https://www.semanticscholar.org/paper/4f5c1dc3e73b2dfaecd53668472791a6b26f2152

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. C. V. Dang
2. J. Richards
3. Craig B. Thompson
4. Guido Kroemer
5. Russell G. Jones
6. M. Larance
7. Angus I. Lamond
8. J. Pouysségur

In Cancer Research

1. C. V. Dang
2. Ralph J. Deberardinis
3. G. Semenza
4. Craig B. Thompson
5. Guido Kroemer
6. J. Pouysségur
7. Russell G. Jones
8. J. Rathmell

In Genetics

1. C. V. Dang
2. G. Semenza
3. J. Richards
4. Russell G. Jones
5. J. Pouysségur
6. Guido Kroemer
7. Ralph J. Deberardinis
8. Craig B. Thompson

Citations in the corpus

• Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. (2011, positive): “HIF-1a Expression Is Upregulated in a Stat3-Dependent Manner in T Cells under TH17-Skewing Conditions HIF-1 is a heterodimeric transcription factor consisting of a highly regulated oxygen-sensitive HIF-1a subunit and a constitutively present b subunit (termed HIF-1b) (Semenza, 2007).”
• Tumor cell metabolism: cancer's Achilles' heel. (2008, background): “…M2; SCO2, synthesis of cytochrome c oxidase 2; SDH, succinate dehydrogenase; TSC, tuberous sclerosis complex; VDAC, voltage-dependent anion channel; VHL, von HippelLindau ubiquitin ligase. inflammatory, metabolic, and oxidative stress (Harris, 2002; Semenza, 2007; Taylor and Pouyssegur, 2007).”
• The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche (2010, background): “, 2001) or protein stabilization (Li et al., 2005; Nakayama et al., 2004; Qi et al., 2008; Semenza, 2007).”
• Metabolic Regulation of T Lymphocytes (2013, background): “HIF-1α is best appreciated for its role in the hypoxic response, in which hypoxia reduces HIF-1α prolyl-hydroxylation to prevent HIF1α ubiquitination by the VHL E3 ubiquitin ligase complex (89).”
• MYC on the Path to Cancer (2012, background): “Certain E box-driven metabolic genes are regulated in a circadian rhythm by Clock/Bmal, whereas glycolytic and angiogenic genes can be activated by HIF-1 in response to hypoxia (Asher and Schibler, 2011; Semenza, 2007; Shchors et al., 2006).”
• Chapter 10 Metabolic and Molecular Responses of Fish to Hypoxia (2009, background): “Since its discovery, HIF has been viewed as the molecular master factor of the hypoxic response and a great deal of information is now available on the genes and gene families regulated by HIF (Semenza, 2007; Gardner & Corn, 2008).”
• Tumor suppressors and cell metabolism: a recipe for cancer growth. (2009, background): “This metabolic shift is synchronized by hypoxia-inducible factor 1 (HIF1), a transcription factor complex activated by hypoxic stress (Gordan and Simon 2007; Semenza 2007).”
• Multidimensional proteomics for cell biology (2015, background): “This is a similar role to that of targeted Pro hydroxylation in the regulated degradation of the transcription regulator hypoxia-inducible factor 1α (HIF1α) 102 .”