More hippocampal neurons in adult mice living in an enriched environment

By Gerd Kempermann, H. Kuhn, Fred H. Gage. 1997

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Citations in the corpus

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease 6–10 .”
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment (2006, background): “enrichment is typically paralleled by an enhanced performance in hippocampus-dependent tasks (Kempermann et al., 1997; Nilsson et al., 1999).”
Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice (2008, background): “…hippocampal neurogenesis with altered performance of hippocampus-dependent learning tasks, thus suggesting that ongoing neurogenesis in adulthood could be involved in functions such as memory and learning (Kempermann et al., 1997, 2004; Gould et al., 1999; Shors et al., 2001; Aimone et al., 2006).”
Potential role for adult neurogenesis in the encoding of time in new memories (2006, background): “The effects of environment and behavior on the dynamics of the neurogenesis process are being reveale”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “Neurogenesis could be induced by environmental enrichment (Kempermann et al. 1997; Rossi et al. 2006), hippocampus-dependent learning (Gould 1999), and physical exercise (Aimone et al.”
What is cognitive reserve? Theory and research application of the reserve concept (2002, background): “Further, animal studies suggest that aspects of life experience, including enriched environment ( Kemperman et al., 1997 ) and exercise (van Praag et al., 1999) can increase the amount of new neurons that are generated in mature animals.”
Effects of adverse experiences for brain structure and function. (2000, background): “In the enriched environment studies (Kempermann et al 1997), increased dentate gyrus volume was accompanied by better performance on spatial learning tasks.”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, methodology): “Stereological counting of the hippocampal subfields was done as described previously (Kempermann et al., 1997).”
Functional significance of adult neurogenesis. (2004, background): “Experience of environmental complexity [23] as well as more specific learning stimuli lead to an increased recruitment of new neurons from the pool of dividing progenitor cells [24].”
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “Although the functional significance remains to be proven, the positive association of neurogenesis with ADs and exercise, as well as other beneficial stimulations such as diet, learning, and environmental enrichment (Alvarez-Buylla, 1992; Kempermann et al., 1997; Lee et al., 2000), implicates it as”
Observations on the pre- and post-weaning behaviour of piglets reared in commercial indoor and outdoor environments (2001, background): “…outdoor piglets, like rats and mice exposed to more complex social and physical environments (Anisman et al., 1998; Greenough and Juraska, 1979; Kempermann et al., 1997) may also show a greater capacity to develop new behavioural strategies in response to novel challenges in the post-weaning…”