Potential role for adult neurogenesis in the encoding of time in new memories

By James Bradley Aimone, Janet Wiles, Fred H. Gage. 2006

700 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience, Neuroscience, Cognitive Science & Psychology

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Citations in the corpus

Lifelong Learning of Spatiotemporal Representations With Dual-Memory Recurrent Self-Organization (2018, background): “Alternative theories suggest that an additional function of hippocampal neurogenesis is the encoding of time for the formation of temporal associations in memory (Aimone et al., 2006, 2009), e.g., in terms of temporal clusters of long-term episodic memories.”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “The different potential effects of adult-born DGCs on pattern separation at different timescales has led to an additional hypothesis — namely, that adult-born DGCs contribute to the encoding of temporal informatio”
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory (2009, background): “In line with the proposal that newborn neurons could act as time clusters for the storage of long-term episodic memories, their functional recruitment into hippocampal networks could thus enable better distinction between new and past experiences that are very similar in nature (40).”
Biological underpinnings for lifelong learning machines (2022, background): “Neurogenesis, especially in the dentate gyrus of the hippocampus, is thought to support learning new memories without sacrificing old ones 169,170 .”
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning (2011, neutral): “One theory is that neurogenesis in the adult dentate gyrus is important for fine spatial distinction”
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “]. Alternatively, addition of these new circuits could encode the time of new memories [”
A model of hippocampal neurogenesis in memory and mood disorders. (2007, neutral): “Whereas our previous www.sciencedirect.com model [18,19] accounts for the role of the new neurons in forming distinct event memories, the data reviewed here suggest that these neurons also have a role in linking events across time when the events are part of a common context.”
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, background): “Importantly, the encoding and separation of similar spatial representations (pattern separation) have been shown recently to be highly dependent on adult hippocampal neurogenesis (4, 27, 53, 57, 58).”
Computational influence of adult neurogenesis on memory encoding. (2009, positive): “One possibility that we discussed in our previous report is that this added association relates to time (Aimone et al., 2006).”
Training-induced structural changes in the adult human brain. (2008, background): “Potential correlates of the observed morphometric changes include a simple change in cell size, growth or atrophy of neurons or glia [42], as well as changes in the intracortical axonal architecture (i.e. synaptogenesis) [1] [72].”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “Consequently, the notion has arisen that the enhanced plasticity and excitability of young neurons makes them a preferential substrate for new memories or representations (Aimone et al., 2006; Aimone et al., 2009; Doetsch and Hen, 2005; Kee et al., 2007; Tashiro et al., 2007).”
Hippocampal granule cells opt for early retirement (2010, background): “The excitable population might participate in setting up CA3 representations and then become quiescent for future events, even ones resembling old memories [‘‘temporal tagging’’; (Aimone et al., 2006, 2009)].”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “Alternatively, Aimone et al. (2006) suggested that adding plastic immature neurons into the dentate gyrus would hinder its function in pattern separation.”
Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats (2007, background): “The dentate gyrus (DG) of the HF is one of the areas in which neurons are generated throughout life (Abrous et al., 2005; Aimone et al., 2006).”