Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

By E. De Gregorio, P. Spellman, Gerald M. Rubin, B. Lemaître. Proceedings of the National Academy of Sciences of the United States of America, 2001

717 citations recorded by the source corpus.

Subfields: Immunology, Insect Science

View Paper: https://www.semanticscholar.org/paper/d98736e4d03eed7de3c7dc51f52c8fa9398a7b92

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Insect Science

Citations in the corpus

The Toll and Imd pathways are the major regulators of the immune response in Drosophila (2002, neutral): “( # $ # # # $ # 8 .”
Antimicrobial peptides: Application informed by evolution (2020, result): “These interpretations were fully consistent with strong up-regulation of AMPproduction in response to infection (22) and were superficially consistent with molecular evolutionary and comparative genomic data that showed rapid duplication, deletion, and pseudogenization of individual AMP genes while ”
Drosophila innate immunity: an evolutionary perspective (2002, background): “DIF activates transcription of a large number of genes, probably several hundred, as suggested by genome-wide analysis of Drosophila immune response”
The immune response of Drosophila (2003, background): “However, microarray data have indicated that hundreds of genes are markedly upregulated as a consequence of the challenge-dependent activation of Tol”
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review (2002, methodology): “We required an arbitrary length of 50 amino acids for all annotations not specifically supported by literature references (for example, the DIRG genes [ 42 ]), and 42 of the deleted Release 2 annotations were removed because they failed to meet this criterion (Figure 2a, inset).”
Invertebrate immune systems – not homogeneous, not simple, not well understood (2004, background): “For example, over 230 genes were shown to be induced in adult Drosophila following exposure to microbial infection, many with unknown functions (41).”
Bacterial disease resistance in Arabidopsis through flagellin perception (2004, background): “A similar positive feedback regulation with transcriptional activation of the components involved in the perception and signalling has been reported for the innate immune response in Drosophila”
The host defense of Drosophila melanogaster. (2007, background): “bassiana (initiated by applying fungal spores on the cuticle) leads to the expression of the antifungal peptide genes Drosomycin and Metchnikowin and other Toll-dependent immune genes through a selective activation of the Toll pathway (19, 83).”
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila (2005, background): “Of the genes that were upregulated, two thirds were not upregulated by bacterial or fungal challenges, suggesting a distinct type of respons”