The immune response of Drosophila

By J. Hoffmann. Nature, 2003

1,522 citations recorded by the source corpus.

Subfields: Immunology, Insect Science, Microbiology

View Paper: https://www.semanticscholar.org/paper/cc0a6f485283a64217fe4865d3f959e1952a8ab6

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Citations in the corpus

Recent advances in the innate immunity of invertebrate animals. (2005, background): “Once microbes have entered the haemocoel, they are exposed to humoral and cellular responses (Leclerc and Reichhart, 2004; Waterfield et al., 2004; Abraham and Jacobs-Lorena, 2004).”
Are innate immune signaling pathways in plants and animals conserved? (2005, background): “In comparing the drosophila and mammalian innate immune signaling pathways, the mammalian TLR pathway is made up of components analogous to those found in the proximal and distal portions of the drosophila TLR and Imd pathways, respectivel”
Insect immunity and its signalling: an overview (2010, background): “Fat body is the largest organ of the hemocel, the insect body cavity, and is a major site for the production and secretion of antimicrobial peptides (Hoffmann, 2003).”
An overview of insect innate immunity (2020, background): “Genetic analysis has revealed that promoter regions of insect AMP genes resemble the binding sites of NF-κB/Rel in mammals as they contain the same nucleotide motifs (Ferrandon et al. 2004; Hoffmann 2003).”
Eicosanoid actions in insect cellular immune functions (2006, background): “…complex array of such proteins and led to discovery of entirely new signal transduction systems that link detection of different classes of infecting microbes to expression of specific genes encoding antimicrobial proteins appropriate to the infecting microbe (Hoffmann, 2003; Leulier et al., 2003).”
Innate immune recognition of viral infection (2006, background): “In drosophila, FADD and RIP1 are essential components of the Imd pathway, which mediates antibacterial innate immune response”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “Elements of this system are rooted in similar macrophage-like phagocytic cells found among invertebrates, notably Drosophila, that exhibit striking homology with mammalian innate immune function on both genetic and cellular levels (5).”
Insect immune resistance to parasitoids (2008, background): “…lack adaptive immunity but possess an effective innate immune system that successfully combats infections (Blandin & Levashina, 2004; Brennan & Anderson, 2004; Christensen et al., 2005; Hoffmann, 1995, 2003; Royet, 2004a, 2004b; Siva-Jothy et al., 2005; Stanley, 2006; Tzou et al., 2002).”
The Endosymbiotic Bacterium Wolbachia Induces Resistance to Dengue Virus in Aedes aegypti (2010, background): “largely regulated by two main pathways, the Toll and Imd pathways [17,18].”
The many roles of FAS receptor signaling in the immune system (2009, positive): “…et al., 2000), TLR (Toll-like receptor)-mediated innate immune responses (Balachandran et al., 2004) (a process that notably also requires FADD in Drosophila [Hoffmann, 2003]), TLR-induced proliferation of B cells, and cytokine-induced proliferation of myeloid progenitors (Pellegrini et al., 2005).”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “They are also the most well characterized and recognize a wide range of PAMPs (Akira et al., 2006; Beutler, 2009; Hoffmann, 2003;Medzhitov, 2007).”
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections (2007, neutral): “By contrast, the IMD pathway is similar to the tumour-necrosis factor-receptor (TNFR) pathway in mammal”
The Aedes aegypti Toll Pathway Controls Dengue Virus Infection (2008, background): “melanogaster have shown that arthropod immune responses are largely regulated by two main pathways, the Toll and immune deficiency (Imd) pathways [9,10].”
The biology of blood-sucking in insects (2005, neutral): “, 2001) and GNBP1 (Hoffmann, 2003), but the protease-cleaving Spätzle is unknown.”
The host defense of Drosophila melanogaster. (2007, background): “PPAE also exists as an inactive zymogen that is itself stimulated through a stepwise process involving other SPs. Studies with other insect species indicate that the melanization cascade is triggered by injury or by recognition through PRRs of microbial ligands, such as PGN, β(1,3)-glucan, and LPS (”