Drosophila innate immunity: an evolutionary perspective

By J. Hoffmann, J. Reichhart. Nature Immunology, 2002

1,126 citations recorded by the source corpus.

Subfields: Immunology, Insect Science, Microbiology

View Paper: https://www.semanticscholar.org/paper/0eebc1f3f4ef79f35407d6aced63042f39df6eab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. J. Hoffmann
3. B. Beutler
4. K. Takeda
5. M. J. Lehane
6. Taro Kawai
7. K. Hoebe
8. M. Strand

In Insect Science

1. J. Hoffmann
2. M. J. Lehane
3. Shizuo Akira
4. B. Lemaître
5. M. Strand
6. K. Takeda
7. L. Romani
8. Gerald M. Rubin

In Microbiology

1. Shizuo Akira
2. K. Takeda
3. M. J. Lehane
4. M. Strand
5. B. Lemaître
6. L. Romani
7. B. Beutler
8. J. Hoffmann

Citations in the corpus

• The insect cellular immune response (2008, background): “…primary site of antimicrobial peptide expression, studies in diverse insects reveal that many AMPs are also expressed in hemocytes (Lowenberger, 2001; Hoffmann & Reichhart, 2002; Boman, 2003; Lackie, 1988; Yamano et al., 1994; Dimopoulos et al., 2000; Bartholomay et al., 2004; Irving et al., 2005).”
• Invertebrate immune systems – not homogeneous, not simple, not well understood (2004, background): “For very good reasons, this discovery has been big news: it has been important in revealing how a model invertebrate like Drosophila melanogaster defends itself from bacteria and fungi (1, 2); it is pointing the way to the discovery of a previously unknown and important innate defense system in mamm”
• Toll-like receptors in innate immunity. (2004, positive): “Thus, the Drosophila Toll signaling pathway is very similar to that of mammalian TLR, especially the participation of the adaptor MyD88, the serine/ threonine kinase IRAK, the ankyrin-repeat protein I j B and the Rel-type transcription factor NF-j B (125,126).”
• Immunity to fungal infections (2011, background): “Toll was originally defined as a Drosophila gene that was important for ontogenesis and antimicrobial resistanc”
• The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein (2002, background): “jpg" NDATA ITEM> ]> The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat bod”
• ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005, background): “Genetic evidence has shown that NF-κB-like transcription factors activated 'downstream' of the Toll pathway are pivotal in the innate immune responses of Drosophila melanogaster”
• Trade‐offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFκB signaling (2006, background): “Many metazoan species rely on mechanisms of innate immunity to provide protection from invading micro-organisms and foreign toxic molecules ( Hoffmann & Reichhart, 2002 ).”
• How we detect microbes and respond to them: the Toll‐like receptors and their transducers (2003, background): “Toll of Drosophila does not directly engage microbial ligands but rather a protein ligand (Spaetzle) [30].”
• The biology of blood-sucking in insects (2005, positive): “Insects possess an immune system that has remarkable parallels to the innate immune system seen in vertebrates and similar systems in plants, suggesting innate-type defence systems arose very early in evolutionary history (Hoffmann and Reichhart, 2002; Menezes and Jared, 2002).”
• The Toll and Imd pathways are the major regulators of the immune response in Drosophila (2002, background): “Genetic analyses have shown that AMP genes are regulated by the Toll and Imd pathways (Hoffmann and Reichhart, 2002; Tzou et al., 2002a).”