The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila

By Catherine Dostert, E. Jouanguy, P. Irving, L. Troxler, D. Galiana-Arnoux, C. Hétru, J. Hoffmann, J. Imler. Nature Immunology, 2005

660 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/78ce82a6b83e38285557b2c2a8013792c504331b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology, Evolution, Behavior and Systematics

1. Yanping Chen
2. Jay D. Evans
3. M. Strand
4. Jeffrey A. Harvey

In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. Satoshi Uematsu
4. J. Hoffmann
5. B. Lemaître
6. M. Strand
7. Taro Kawai
8. G. Dimopoulos

In Infectious Diseases

1. G. Dimopoulos
2. Jose L. Ramirez
3. Z. Xi
4. Shizuo Akira

Citations in the corpus

• The Aedes aegypti Toll Pathway Controls Dengue Virus Infection (2008, methodology): “melanogaster in response to Drosophila C virus infection [20], suggesting a potential connection between virus infection and apoptosis.”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “Of great interest in this context is a recent genetic analysis of Drosophila C virus infection in its natural host Drosophila melanogaster, because the findings demonstrate for the first time a conserved function of the JAK-STAT signaling pathway in insect antiviral immunity (Dostert et al., 2005).”
• Insect immune resistance to parasitoids (2008, background): “Tel: +33 1 69823711; email: carton@legs.cnrs-gif.fr documented for many insects, and non-self recognition receptors and immune-signalling pathways are on the way to being characterized (Dostert et al., 2005; Du Pasquier, 2005; Minakhina & Steward, 2006).”
• Immune pathways and defence mechanisms in honey bees Apis mellifera (2006, background): “Of the dozens of described actors in four signalling pathways predicted to play a role in insect immunity, only one protein appears to be completely absent in the bee genome: the ligand unpaired from the JAK/STAT pathway.”
• The insect cellular immune response (2008, background): “Infection by some viruses activate the Toll and Imd pathways while others stimulates Jak-STAT signaling (Dostert et al., 2005; Zambon et al., 2006).”
• The host defense of Drosophila melanogaster. (2007, background): “They are, however, sensitive to infection with the Drosophila C virus (91).”
• The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster (2008, neutral): “ago-2, and hop [36,38,40].”
• Pathogen recognition and innate immunity. (2006, positive): “Drosophila antiviral immune responses are less understood, although it is known that there are JAK-STAT-dependent and -independent pathways modulating transcriptional responses against Drosophila C virus infection (Dostert et al., 2005).”