The Toll and Imd pathways are the major regulators of the immune response in Drosophila

By E. De Gregorio, P. Spellman, P. Tzou, Gerald M. Rubin, B. Lemaître. EMBO Journal, 2002

908 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Insect Science

View Paper: https://www.semanticscholar.org/paper/7c3eb448d9139906f11f4c74490fe3cab40f3f7c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Hoffmann
2. B. Lemaître

In Immunology

1. J. Hoffmann
2. B. Lemaître
3. G. Dimopoulos
4. N. Moran
5. Philipp Engel
6. Z. Xi
7. Jose L. Ramirez
8. A. Nappi

In Insect Science

1. J. Hoffmann
2. B. Lemaître
3. Philipp Engel
4. N. Moran
5. G. Dimopoulos
6. Z. Xi
7. Jose L. Ramirez
8. A. Nappi

Citations in the corpus

• The host defense of Drosophila melanogaster. (2007, background): “Microarray studies using imd /Toll double mutant flies have shown that these cascades regulate almost 80% of the genes induced upon septic injury, reflecting their important contribution in survival from infection (49).”
• The Aedes aegypti Toll Pathway Controls Dengue Virus Infection (2008, background): “melanogaster have shown that arthropod immune responses are largely regulated by two main pathways, the Toll and immune deficiency (Imd) pathways [9,10].”
• Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections (2007, background): “Although this response depends largely on the Toll and imd pathway”
• The Drosophila Toll Signaling Pathway (2011, background): “The same holds for the Relish,spz, and Relish, Toll double mutants compared with Relish mutants (88).”
• Insect immune resistance to parasitoids (2008, background): “…the PO-mediated melanization cascade in Drosophila is negatively regulated by the serine protease inhibitor (serpin) Spn27A, which inhibits PPAE (De Gregorio et al., 2002a), and is activated by the Toll © 2008 The Authors Journal compilation © Institute of Zoology, Chinese Academy of Science,…”
• The gut microbiota of insects - diversity in structure and function. (2013, background): “In the systemic immune response of D. melanogaster, Toll and IMD are the two major signaling pathways inducing AMP production (Lemaitre et al., 1995, 1996; De Gregorio et al., 2002).”
• The Drosophila immune system detects bacteria through specific peptidoglycan recognition (2003, background): “Each of these pathways leads to the activation of specific NF-κB transactivators, which in turn activate specific programs of transcriptio”
• The Endosymbiotic Bacterium Wolbachia Induces Resistance to Dengue Virus in Aedes aegypti (2010, background): “largely regulated by two main pathways, the Toll and Imd pathways [17,18].”
• Trade‐offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFκB signaling (2006, background): “The Drosophila genome encodes at least 15 antimicrobial peptides (AMPs) (Werner et al ., 2003) and three NF κ B-like molecules, with the Toll pathway primarily responsible for protection from fungal and Gram-positive bacteria infections, and the Imd pathway mainly responsible for protection from Gra”
• The immune response of Drosophila (2003, background): “The functions of most of these genes in host defence remain to be establishe”