Opiates inhibit neurogenesis in the adult rat hippocampus.

By A. Eisch, M. Barrot, C. Schad, D. Self, Eric J. Nestler. Proceedings of the National Academy of Sciences of the United States of America, 2000

625 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/d92d202b4884722239e164fc4a5e0140c1031153

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Citations in the corpus

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus (2001, background): “…neurogenesis in this region (Cameron and Gould, 1994; Cameron et al., 1995; Gould et al., 1997; Brezun and Daszuta, 1999; Tanapat et al., 1999; Eisch et al., 2000); the rapid time course of this regulation suggests that these factors also produce their effects through alterations in the…”
Molecular basis of long-term plasticity underlying addiction (2001, background): “Chronic exposure to opiates also reduces the birth of new neurons in the adult hippocampu”
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning (2002, background): “…female estrous cycle affect both neurogenesis and learning, as do drug-induced changes such as those that occur in response to opiate and antidepressant administration (Cameron and Gould, 1994; Shors et al., 1998; Tanapat et al., 1999; Eisch et al., 2000; Malberg et al., 2000; Wood et al., 2001).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “Chronic administration of morphine and heroin, drugs that act on the opioid signalling system, decreases neurogenesis in the adult rat hippocampu”
Neurogenesis and Exercise: Past and Future Directions (2008, background): “However, exogenous opiate agonists such as morphine and heroin have been shown to suppress neurogenesis in vivo, and knockout of the mu opioid receptor increases neurogenesis (Eisch et al. 2000; Harburg et al. 2007).”
Identification of Astrocyte-expressed Factors That Modulate Neural Stem/Progenitor Cell Differentiation (2006, positive): “Activation of the delta opioid system has been shown to inhibit adult hippocampal neurogenesis (34,35), and we hypothesized that enkephalin may directly inhibit NSPC neuronal differentiation.”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “(137) were the first to demonstrate that the exogenous chronic (daily implantation of subcutaneous pellets containing 75 mg morphine during 5 days) and not acute (10 mg/kg) administration of morphine decreases cell proliferation in the GCL by 28% (measured 2 h after an injection of BrdU, 100 mg/kg, ”
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6 (2002, background): “Postnatal neurogenesis generally declines in response to noninjurious stressful conditions (Gould et al., 1997; Eisch et al., 2000; Lemaire et al., 2000), but the functional consequences of this decrement remain largely unknown.”
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus (2001, background): “…can influence the rates of cell proliferation and differentiation of new neurons in the dentate gyrus (Gould et al., 1992; Parent et al., 1997; Eisch et al., 2000) The primary precursors in the SVZ, the other germinal region of the adult brain, have been identified recently as having the…”
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus (2000, methodology): “In addition, we have found that chronic administration of morphine decreases granule cell proliferation, an effect opposite to that of antidepressant treatment (Eisch et al., 2000).”