Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6

By L. Vallières, I. Campbell, Fred H. Gage, P. Sawchenko. Journal of Neuroscience, 2002

617 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b7a77596dd981bad343c3c92ae0ea4a6c654f492

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. D. Abrous
2. P. Carpentier
3. H. Schmidt
4. R. Duman
5. T. Palmer
6. M. Le Moal
7. M. Koehl
8. Fred H. Gage

In Neurology

1. David J. Loane
2. R. Duman
3. T. Palmer
4. P. Carpentier
5. D. Abrous
6. Alok Kumar
7. J. Fike
8. Michelle Monje

Citations in the corpus

• Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “It appears that similar mechanisms are conserved between NSCs in development and in the adult because overexpression of IL-6 by astrocytes in the adult also impairs neurogenesis within the hippocampus (Vallieres et al., 2002), and much can be gleaned from the ongoing neurodevelopmental studies for p”
• Irradiation induces neural precursor-cell dysfunction (2002, background): “Differentiation of neural precursor cells depends on a specific neurogenic microenvironment and is influenced by intercellular cue”
• Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. (2003, background): “Given the potential role of proinflammatory cytokines in radiation brain injury (53–55), and the impact of specific cytokines on neurogenesis (56), it is possible that the activation of microglia may constitute a critical factor in the radiation-induced depression of neuron production.”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Unauthorized reproduction of this article is prohibited. part, by a balance between proinflammatory and antiinflammatory cytokines, including IL-1b (Kaneko et al., 2006; Koo and Duman, 2006; Wachs et al., 2006), IL-6 (Vallieres et al., 2002; Monje et al., 2003), tumor necrosis factor-a (Iosif et al.”
• Identification of Astrocyte-expressed Factors That Modulate Neural Stem/Progenitor Cell Differentiation (2006, neutral): “GFAP promoter-IL-6 transgenic mice exhibit a 63% reduction in adult hippocampal neurogenesis and significantly reduced neuronal differentiation of NSCs in vivo (14).”
• Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…demonstrated that several pro-inflammatory cytokines produced by M1-like microglia and macrophages, such as IFNγ, IL-1β, TNFα, and IL-6, can also suppress neurogenesis (Ben-Hur et al., 2003; Cacci et al., 2005; Iosif et al., 2008; Koo and Duman, 2008; Monje et al., 2003; Vallieres et al., 2002).”
• Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia (2008, background): “An amplified or excessive inflammatory cytokine response in the brain, however, is associated with a myriad of complications including cognitive dysfunction [ 7- 10 ], prolonged sickness behavior [11-14], and depressivelike behavior [15].”
• Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “For example, transgenic mice whose astrocytes overexpress IL-6 develop neurological disease (47) and exhibit impaired long-term potentiation (48), avoidance learning (49), and neurogenesis (50).”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “355, 466, 565), 2) chronic stress increases its production in aged patients (272), 3) IL-6 expression is increased in the HF of senescence-accelerated mice (539), and 4) hippocampal neurogenesis is reduced in adult transgenic mice with chronic IL-6 production (552) or after administration of bacteri”
• Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “GFAP-IL6 mice, indeed, show a diminished hippocampal neurogenesis [82], and moreover, in vitro IL-6 clearly decreases the differentiation of neural stem/progenitor cells into neurons [83, 84].”